Western Blot (WB)
(The recombinant human alpha-synuclein domains were resolved by SDS-PAGE, transferred to PVDF membrane and probed with MBS6006217 (1:1000). Proteind were visualized using IgG (HRP) goat anti-mouse secondary antibody and an ECL detection systemLane 1: Recombinant human α-synuclein (1-60aa)Lane 2: Recombinant human α-synuclein (1-95aa)Lane 3: Recombinant human α-synuclein (61-140aa)Lane 4: Recombinant human α-synuclein (96-140aa))
Mouse anti-Human Synuclein, alpha, aa61-95 Monoclonal Antibody | anti-SNCA antibody
Synuclein, alpha, aa61-95 (SNCA, 127750, P37840, MGC110988, NACP, PARK1, PARK4, non-A beta Component of AD Amyloid, NACP, Parkinson Disease Familial 1, PD1)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Dilution: ELISA: 1:1000-1:2000
Western Blot: 1:500-1:2000
Western Blot (WB)
(The recombinant human alpha-synuclein domains were resolved by SDS-PAGE, transferred to PVDF membrane and probed with MBS6006217 (1:1000). Proteind were visualized using IgG (HRP) goat anti-mouse secondary antibody and an ECL detection systemLane 1: Recombinant human α-synuclein (1-60aa)Lane 2: Recombinant human α-synuclein (1-95aa)Lane 3: Recombinant human α-synuclein (61-140aa)Lane 4: Recombinant human α-synuclein (96-140aa))
Western Blot (WB)
(The recombinant human alpha-synuclein domains were resolved by SDS-PAGE, transferred to PVDF membrane and probed with MBS6006217 (1:1000). Proteind were visualized using IgG (HRP) goat anti-mouse secondary antibody and an ECL detection systemLane 1: Recombinant human α-synuclein (1-60aa)Lane 2: Recombinant human α-synuclein (1-95aa)Lane 3: Recombinant human α-synuclein (61-140aa)Lane 4: Recombinant human α-synuclein (96-140aa))
Western Blot (WB)
(The recombinant human alpha-synuclein domains were resolved by SDS-PAGE, transferred to PVDF membrane and probed with MBS6006217 (1:1000). Proteind were visualized using IgG (HRP) goat anti-mouse secondary antibody and an ECL detection systemLane 1: Recombinant human α-synuclein proteinLane 2:Recombinant human β-synuclein proteinLane 3: Recombinant human γ-synuclein protein)
Western Blot (WB)
(The recombinant human alpha-synuclein domains were resolved by SDS-PAGE, transferred to PVDF membrane and probed with MBS6006217 (1:1000). Proteind were visualized using IgG (HRP) goat anti-mouse secondary antibody and an ECL detection systemLane 1: Recombinant human α-synuclein proteinLane 2:Recombinant human β-synuclein proteinLane 3: Recombinant human γ-synuclein protein)
Immunofluoresence/Immunocytochemistry (IF/ICC)
(Immunocytochemistry/Immunofluoresence α-synuclein in HeLa cells. The cells were stained with MBS6006217 (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the nucleus (blue).)
Immunofluoresence/Immunocytochemistry (IF/ICC)
(Immunocytochemistry/Immunofluoresence α-synuclein in HeLa cells. The cells were stained with MBS6006217 (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the nucleus (blue).)
NCBI and Uniprot Product Information
NCBI Description
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
Uniprot Description
SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4q21
Cellular Component: Golgi apparatus; nuclear outer membrane; mitochondrion; rough endoplasmic reticulum; lysosome; fibril; extracellular region; terminal button; cell cortex; inclusion body; mitochondrial respiratory chain complex I; cytosol; actin cytoskeleton; synaptic vesicle; platelet alpha granule membrane; growth cone; axon; perinuclear region of cytoplasm; cytoplasm; plasma membrane; ribosome; cell junction; nucleus
Molecular Function: identical protein binding; protein domain specific binding; histone binding; zinc ion binding; kinesin binding; ferrous iron binding; microtubule binding; caspase inhibitor activity; magnesium ion binding; beta-tubulin binding; phosphoprotein binding; protein N-terminus binding; calcium ion binding; Hsp70 protein binding; oxidoreductase activity; dynein binding; protein binding; phospholipase binding; copper ion binding; phospholipid binding; tau protein binding; fatty acid binding; alpha-tubulin binding
Biological Process: regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; regulation of acyl-CoA biosynthetic process; positive regulation of apoptosis; adult locomotory behavior; mitochondrial membrane organization and biogenesis; negative regulation of norepinephrine uptake; microglial cell activation; positive regulation of endocytosis; response to lipopolysaccharide; dopamine biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of monooxygenase activity; negative regulation of caspase activity; fatty acid metabolic process; positive regulation of neurotransmitter secretion; regulation of dopamine secretion; negative regulation of dopamine uptake; negative regulation of histone acetylation; calcium ion homeostasis; negative regulation of exocytosis; response to magnesium ion; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; phospholipid metabolic process; receptor internalization; synapse organization and biogenesis; fibril organization and biogenesis; dopamine uptake; response to iron(II) ion; negative regulation of neuron apoptosis; positive regulation of receptor recycling; aging; caspase activation; response to drug; neutral lipid metabolic process; protein destabilization; regulation of glutamate secretion; negative regulation of microtubule polymerization; regulation of macrophage activation; positive regulation of peptidyl-serine phosphorylation; negative regulation of dopamine metabolic process; organelle ATP synthesis coupled electron transport; regulation of locomotion; synaptic vesicle endocytosis; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential; negative regulation of transporter activity; negative regulation of apoptosis
Disease: Parkinson Disease 4, Autosomal Dominant; Dementia, Lewy Body; Parkinson Disease 1, Autosomal Dominant
Research Articles on SNCA
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Product Notes
The SNCA snca (Catalog #AAA6006217) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Synuclein, alpha, aa61-95 (SNCA, 127750, P37840, MGC110988, NACP, PARK1, PARK4, non-A beta Component of AD Amyloid, NACP, Parkinson Disease Familial 1, PD1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Synuclein, alpha, aa61-95 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: ELISA: 1:1000-1:2000 Western Blot: 1:500-1:2000. Researchers should empirically determine the suitability of the SNCA snca for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Synuclein, alpha, aa61-95, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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