alpha-Synuclein Recombinant Protein | SNCA recombinant protein
alpha-Synuclein (lyophilized), 1-140aa, Human, E Coli
Gene Names
SNCA; PD1; NACP; PARK1; PARK4
Applications
SDS-Page
Purity
> 95% by SDS-PAGE
Synonyms
alpha-Synuclein; alpha-Synuclein (lyophilized); 1-140aa; Human; E Coli; SNCA; NACP; PARK1; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; Alpha synuclein; Alpha-synuclein isoform NACP140; alphaSYN; MGC105443; MGC110988; MGC127560; MGC64356; Non A beta component of AD amyloid; Non A4 component of amyloid precursor; Non-A-beta component of alzheimers disease amyloid; precursor of PARK 1; PARK 4; PARK4; Parkinson disease familial 1; PD 1; PD1; Synuclein alpha; ; SNCA recombinant protein
Host
E Coli
Purity/Purification
> 95% by SDS-PAGE
Form/Format
Lyophilized from a 0.2 um filtered in 20 mM Tris-HCl Buffer, (pH 7.5), 100 mM NaCl, 1mM MgCl2
Sequence
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Sequence Length
140
Applicable Applications for SNCA recombinant protein
SDS-PAGE
Antigen Species
Human
Immunogen
Reconstitute in sterile distilled water at a concentration of 1mg/ml or less.
Endotoxin Level
< 1.0 EU per 1 microgram of protein (determined by LAL method)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
SDS-Page
Related Product Information for SNCA recombinant protein
alpha-Synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that alpha-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140).
Product Categories/Family for SNCA recombinant protein
References
Jakes, R., et al. (1994) FEBS lett. 345, 27-32; ueda, K., et al. (1993) Proc. Natl. Acad. Sci. uSA 90, 11282-11286; Kim, J. (1997) Molecules and Cells 7, 78-83; Paik, S. R., et al. (1997) Arch. Biochem. Biophys. 344, 325-334.;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
14.4 kDa (140 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
NCBI Official Full Name
alpha-synuclein isoform NACP140
NCBI Official Synonym Full Names
synuclein alpha
NCBI Official Symbol
SNCA
NCBI Official Synonym Symbols
PD1; NACP; PARK1; PARK4
NCBI Protein Information
alpha-synuclein
UniProt Protein Name
Alpha-synuclein
Protein Family
UniProt Gene Name
SNCA
UniProt Synonym Gene Names
NACP; PARK1; NACP
NCBI Description
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Uniprot Description
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
