Mouse anti-Human SSR1 Monoclonal Antibody | anti-SSR1 antibody

Anti-SSR1 Antibody (clone 1A12)

Cat. Num. AAA2400608

• Gene Names: SSR1; TRAPA
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Purified from ascites by Protein A
• Synonyms: SSR1; Monoclonal Antibody; Anti-SSR1 Antibody (clone 1A12); Mouse Monoclonal [clone 1A12] (IgG1; k) to Human SSR1; Signal sequence receptor; SSR-alpha; TRAP-alpha; TRAP alpha; Ssr; SSR alpha subunit; Trap-a; TRAPA; anti-SSR1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, k
• Clone Number: 1A12
• Specificity: Human SSR1
• Purity/Purification: Purified from ascites by Protein A
• Form/Format: PBS, pH 7.4
• Sequence Length: 286

• Applicable Applications for anti-SSR1 antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: IHC-P: 5 ug/ml; WB: 1:500-1:1000
• Immunogen: SSR1 (AAH07710, 33 a.a. ~ 287 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C or lower.; Aliquot to avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-TRAP alpha antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Antibody Western blot of SSR1 expression in HL-60.)

ELISA (EIA)

(Detection limit for recombinant GST tagged SSR1 is approximately 1 ng/ml as a capture antibody.)

Related Product Information for anti-SSR1 antibody

sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER)membrane receptor associated with protein translocation across the ERmembrane. the SSR consists of 2 subunits, a 34-kD glycoprotein(alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). the human alpha-signal sequence receptor gene (SSR1), also referred to asTRAP alpha, maps to the short arm of chromosome 6. SSR1 has several mRNAspecies as a result of complex alternative polyadenylation.

NCBI and Uniprot Product Information

• NCBI GI #: 169404009
• NCBI GeneID: 6745
• NCBI Accession #: NP_003135.2
• NCBI GenBank Nucleotide #: NM_003144.4
• UniProt Accession #: P43307; Q53GX2; Q53H19; Q5TAM3; Q6IB43; Q8NBH9; Q96IA2; Q9TNQ8; Q9UN49; A8K685
• Molecular Weight: 29,373 Da
• NCBI Official Full Name: translocon-associated protein subunit alpha isoform 1
• NCBI Official Synonym Full Names: signal sequence receptor subunit 1
• NCBI Official Symbol: SSR1
• NCBI Official Synonym Symbols: TRAPA
• NCBI Protein Information: translocon-associated protein subunit alpha
• UniProt Protein Name: Translocon-associated protein subunit alpha
• Protein Family: SWI/SNF and RSC complexes
• UniProt Gene Name: SSR1
• UniProt Synonym Gene Names: TRAPA; TRAP-alpha; SSR-alpha

NCBI Description

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Uniprot Description

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.