Mouse anti-Human SorCS3 Monoclonal Antibody | anti-SORCS3 antibody

SorCS3 (VPS10 domain-containing receptor SorCS3, SORCS3, KIAA1059)

Cat. Num. AAA604985

• Gene Names: SORCS3; SORCS; RP11-107L7.1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: SorCS3; Monoclonal Antibody; SorCS3 (VPS10 domain-containing receptor SorCS3; SORCS3; KIAA1059); Anti -SorCS3 (VPS10 domain-containing receptor SorCS3; anti-SORCS3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: 9G445
• Specificity: Recognizes human SorCS3.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a lyophilized powder from PBS, pH 7.2. Reconstitute with 100ul sterile ddH2O.

• Applicable Applications for anti-SORCS3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use ELISA and Western Blot.
• Immunogen: Partial recombinant human SorCS3 (aa1147-1222) with a GST tag.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot detection of GST tagged recombinant human SorCS3 using MBS604985.)

Related Product Information for anti-SORCS3 antibody

SorCS3 is a family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. It is noted that all mammalian VPS10 domains carry an N-terminal signal peptide for translocation into the endoplasmic reticulum. The greatest similarity between the receptors is found in the C-terminal parts of the VPS10 domains, which harbor 12 cysteine residues with a characteristic spacing conserved in all VPS10 proteins from yeast to man. SorCS3 is a single-pass type I membrane protein that is highly expressed in brain.

Product Categories/Family for anti-SORCS3 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 28374159
• NCBI GeneID: 22986
• UniProt Accession #: Q86XB2; Q17R88; Q9UPU3
• Molecular Weight: 29,352 Da
• NCBI Official Full Name: SORCS3 protein
• NCBI Official Synonym Full Names: sortilin-related VPS10 domain containing receptor 3
• NCBI Official Symbol: SORCS3
• NCBI Official Synonym Symbols: SORCS; RP11-107L7.1
• NCBI Protein Information: VPS10 domain-containing receptor SorCS3; 6330404A12Rik; OTTHUMP00000020444; VPS10 domain receptor protein SORCS 3 (SORCS3)
• UniProt Protein Name: SORCS3 protein
• Protein Family: VPS10 domain-containing receptor
• UniProt Gene Name: SORCS3
• UniProt Entry Name: Q86XB2_HUMAN

NCBI Description

This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. [provided by RefSeq]

Uniprot Description

SORCS3: one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. [provided by RefSeq, Jul 2008]

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q23-q25

Cellular Component: membrane; integral to membrane

Molecular Function: neuropeptide receptor activity

Biological Process: neuropeptide signaling pathway; learning; memory