Mouse anti-Human SORCS3 Monoclonal Antibody | anti-SORCS3 antibody

SORCS3 (VPS10 Domain-containing Receptor SorCS3, KIAA1059) (HRP)

Cat. Num. AAA6155136

• Gene Names: SORCS3; SORCS
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SORCS3; Monoclonal Antibody; SORCS3 (VPS10 Domain-containing Receptor SorCS3; KIAA1059) (HRP); RP11-107L7.1; anti-SORCS3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a,k
• Clone Number: 3B12
• Specificity: Recognizes human SORCS3.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).
• Sequence Length: 5575

• Applicable Applications for anti-SORCS3 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Partial recombinant corresponding to aa1147-1223 from SORCS3 (NP_055793) with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: KRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFTEPEELLDKELDTRVIGGIATIANSESTKEIPNCTSV*
• Conjugate: HRP
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot detection against Immunogen (34.47kD).)

Product Categories/Family for anti-SORCS3 antibody

Antibodies; Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 1519243031
• NCBI GeneID: 22986
• NCBI Accession #: NM_014978.3
• NCBI GenBank Nucleotide #: NM_014978
• UniProt Accession #: Q9UPU3
• NCBI Official Full Name: Homo sapiens sortilin related VPS10 domain containing receptor 3 (SORCS3), mRNA
• NCBI Official Synonym Full Names: sortilin related VPS10 domain containing receptor 3
• NCBI Official Symbol: SORCS3
• NCBI Official Synonym Symbols: SORCS
• NCBI Protein Information: VPS10 domain-containing receptor SorCS3
• UniProt Protein Name: VPS10 domain-containing receptor SorCS3
• Protein Family: VPS10 domain-containing receptor
• UniProt Gene Name: SORCS3
• UniProt Synonym Gene Names: KIAA1059
• UniProt Entry Name: SORC3_HUMAN

NCBI Description

This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing. [provided by RefSeq, Dec 2014]