Mouse anti-Human Sorcin Monoclonal Antibody | anti-SRI antibody
Sorcin (SRI, 22kD Protein, CP-22, V19) (Azide Free)
Purified by ammonium sulfate precipitation.
Purified by ammonium sulfate precipitation.
Dilution: Western Blot: 1:500-1:1000
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]
Uniprot Description
SRI: Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.
Protein type: Calcium-binding
Chromosomal Location of Human Ortholog: 7q21.1
Cellular Component: nucleoplasm; endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; mitochondrion; sarcoplasmic reticulum; membrane; T-tubule; cytoplasm; nerve terminal; Z disc; cytosol
Molecular Function: protein binding; protease binding; protein heterodimerization activity; calcium channel regulator activity; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding; receptor binding
Biological Process: regulation of action potential; muscle development; cytoplasmic sequestering of transcription factor; negative regulation of heart rate; heart development; regulation of striated muscle contraction; regulation of calcium ion transport; signal transduction; proteolysis; regulation of heart contraction; transport; calcium ion transport; positive regulation of release of sequestered calcium ion into cytosol; intracellular sequestering of iron ion
Research Articles on SRI
2. Tetrandrine reverses multidrug-resistance of K562/A02 cells through regulation of expression of SORCIN.
3. Sorcin interacts with and modulates ryanodine receptor activity in rat vascular smooth muscle cells.
4. provide a plausible structural and functional framework that helps elucidate the phenotypic alterations of mice overexpressing F112L-sorcin
5. relationship between soluble resistance-related calcium-binding protein (sorcin) gene and multidrug resistance gene (mdr1), and their significance in clinical drug resistance and prognosis of acute myeloid leukemia (AML)
6. Knock-down of SRI induces up-regulation of MDR1 in HeLa cells.
7. SRI interacts with GCA in vivo and in vitro.
8. Sorcin gene overexpression is significantly associated with clinical multidrug resistance and prognosis, it is one of the indicators for predicting prognosis of acute myeloid leukemia patients
9. sorcin plays an important role in the emergence of MDR in leukemia cells via regulating cell apoptosis pathways
10. Semi-quantitative RT-PCR experiments with 6 of those genes confirmed higher expression of DNCH2, ARHGEF6, NPM1 and SRI and lower expression of NRGN and TM4SF2 in GBM tumors.
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Product Notes
The SRI sri (Catalog #AAA602879) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Sorcin (SRI, 22kD Protein, CP-22, V19) (Azide Free) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Sorcin can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: Western Blot: 1:500-1:1000. Researchers should empirically determine the suitability of the SRI sri for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Sorcin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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