Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of SLC38A1 protein using Mouse Anti-SLC38A1 Monoclonal Antibody, Clone S104-32. Primary Antibody: Mouse Anti-SLC38A1 Monoclonal Antibody at 1:1000.)
Mouse SNAT1 Monoclonal Antibody | anti-Slc38a1 antibody
SNAT1 Antibody: ATTO 390
Gene Names
Slc38a1; Ata1; GlnT; Sat1
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, Immunocytochemistry
Synonyms
SNAT1; Monoclonal Antibody; SNAT1 Antibody: ATTO 390; SLC38A1; amino acids transporter A1; ATA1; NAT2; sodium coupled neutral amino acids transporter 1; Amino acid transporter system A1; N-system amino acid transporter 2; S38A1; SAT1; SNAT 1; Solute carrier family 38 member 1; System A amino acid transporter; anti-Slc38a1 antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
S104-32
Form/Format
Protein G Purified
Concentration
1mg/mL (varies by lot)
Sequence Length
485
Applicable Applications for anti-Slc38a1 antibody
Immunohistochemistry (IHC), Western Blot (WB), Immunocytochemistry (ICC)
Application Notes
1:1000 (WB)
Conjugate
ATTO 390
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide.
Preparation and Storage
-20 degree C
Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of SLC38A1 protein using Mouse Anti-SLC38A1 Monoclonal Antibody, Clone S104-32. Primary Antibody: Mouse Anti-SLC38A1 Monoclonal Antibody at 1:1000.)
Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of SLC38A1 protein using Mouse Anti-SLC38A1 Monoclonal Antibody, Clone S104-32. Primary Antibody: Mouse Anti-SLC38A1 Monoclonal Antibody at 1:1000.)
Related Product Information for anti-Slc38a1 antibody
Background Info: Detects ~50kDa
Scientific Background: The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family include System A subtypes SNAT1, SNAT2 and SNAT4 and System N subtypes SNAT3 and SNAT5. The SLC38 transporters are essential for the uptake of nutrients, energy production, metabolism, detoxification, and the cycling of neurotransmitters. The SNAT1 protein, also designated ATA1 or NAT2 is encoded by the human gene SLC38A1 which maps to chromosome 12q13.11. SNAT1 is responsible for the transport of glutamine, an intermediate in the synthesis of urea, and may be involved in the generation of glutamate in the retina. SNAT1 protein may be detected in some tissues such as heart, brain and placenta and expression levels are enriched in certain neuronal populations within the CNS. SNAT1 is not present in astrocytes.
Scientific Background: The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family include System A subtypes SNAT1, SNAT2 and SNAT4 and System N subtypes SNAT3 and SNAT5. The SLC38 transporters are essential for the uptake of nutrients, energy production, metabolism, detoxification, and the cycling of neurotransmitters. The SNAT1 protein, also designated ATA1 or NAT2 is encoded by the human gene SLC38A1 which maps to chromosome 12q13.11. SNAT1 is responsible for the transport of glutamine, an intermediate in the synthesis of urea, and may be involved in the generation of glutamate in the retina. SNAT1 protein may be detected in some tissues such as heart, brain and placenta and expression levels are enriched in certain neuronal populations within the CNS. SNAT1 is not present in astrocytes.
Product Categories/Family for anti-Slc38a1 antibody
References
1. Hatanaka T., et al. (2000) Biochim. Biophys. Acta 1467: 1-6. 2. Wang H., et al. (2000) Biochem. Biophys. Res. Commun. 273: 1175-1179. 3. Gu S., et al. (2001) J. Biol. Chem. 276: 24137-24144. 4. Freeman T.L., et al. (2002) Arch. Biochem. Biophys. 400: 215-222. 5. Palii S.S., et al. (2004) J. Biol. Chem. 279: 3463-3471. 6. Sidoryk M., et al. (2004) Neuroreport. 15: 575-578. Erratum in: 2004. Neuroreport. 15: 533. 7. Desforges,M., et al. (2006) Am. J. Physiol. Cell. Physiol. 290: 305-312.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
53,846 Da
NCBI Official Full Name
sodium-coupled neutral amino acid transporter 1
NCBI Official Synonym Full Names
solute carrier family 38, member 1
NCBI Official Symbol
Slc38a1
NCBI Official Synonym Symbols
Ata1; GlnT; Sat1
NCBI Protein Information
sodium-coupled neutral amino acid transporter 1; rATA1; glutamine transporter; system A transporter 2; amino acid transporter A1; amino acid transporter system A1; N-system amino acid transporter 2; system A amino acid transporter 1; system N amino acid transporter 1
UniProt Protein Name
Sodium-coupled neutral amino acid transporter 1
Protein Family
UniProt Gene Name
Slc38a1
UniProt Synonym Gene Names
Ata1; Glnt; Sa2; Sat1; Snat1; rATA1
UniProt Entry Name
S38A1_RAT
NCBI Description
Na(+)-dependent glutamine transporter; may modulate presynaptic glutamatergic function [RGD, Feb 2006]
Uniprot Description
SLC38A1: Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA. Belongs to the amino acid/polyamine transporter 2 family.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral
Cellular Component: membrane; axon; integral to plasma membrane; plasma membrane
Molecular Function: symporter activity; L-glutamine transmembrane transporter activity; amino acid transmembrane transporter activity
Biological Process: sodium ion transport; glutamine transport
Research Articles on Slc38a1
1. Oxidative stress increases SNAT1 expression and stimulates cysteine uptake in rat cardiomyocytes.
Similar Products
Product Notes
The Slc38a1 slc38a1 (Catalog #AAA801224) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The SNAT1 Antibody: ATTO 390 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SNAT1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB), Immunocytochemistry (ICC). 1:1000 (WB). Researchers should empirically determine the suitability of the Slc38a1 slc38a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SNAT1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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