Western Blot (WB)
(Western Blot detection against Immunogen (37.66kD).)
Mouse anti-Human SF3A2 Monoclonal Antibody | anti-SF3A2 antibody
SF3A2 (Splicing Factor 3A Subunit 2, PRP11, PRPF11, SF3a66, Spliceosome-associated Protein 62, SAP 62, SAP62)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: Immunofluorescence: 10ug/ml
Western Blot (WB)
(Western Blot detection against Immunogen (37.66kD).)
Western Blot (WB)
(Western Blot detection against Immunogen (37.66kD).)
Immunofluorescence (IF)
(Immunofluorescence of monoclonal antibody to SF3A2 on HeLa cell. [antibody concentration 10ug/ml.)
Immunofluorescence (IF)
(Immunofluorescence of monoclonal antibody to SF3A2 on HeLa cell. [antibody concentration 10ug/ml.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
Subunit structure: Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Identified in the spliceosome C complex. Interacts with HTATSF1. Ref.7 Ref.9
Subcellular location: Nucleus
By similarity.
Sequence similarities: Belongs to the SF3A2 family.Contains 1 matrin-type zinc finger.
Research Articles on SF3A2
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Product Notes
The SF3A2 sf3a2 (Catalog #AAA649966) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The SF3A2 (Splicing Factor 3A Subunit 2, PRP11, PRPF11, SF3a66, Spliceosome-associated Protein 62, SAP 62, SAP62) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SF3A2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunofluorescence (IF). Suitable for use in ELISA, Immunofluorescence and Western Blot. Dilution: Immunofluorescence: 10ug/ml. Researchers should empirically determine the suitability of the SF3A2 sf3a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: IGRPGYKVTK QRDSEMGQQS LLFQIDYPEI AEGIMPRHRF MSAYEQRIEP PDRRWQYLLM AAEPYETIAF KVPSREIDKA EGKFWTHWNR ETKQFFLQFH FKMEK*. It is sometimes possible for the material contained within the vial of "SF3A2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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