Rabbit anti-Mouse SERPINA6  Monoclonal Antibody | anti-SERPINA6  antibody

Rabbit anti Mouse SERPINA6  Monoclonal Antibody

Cat. Num. AAA2544547

• Gene Names: SERPINA6; CBG
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: SERPINA6 ; Monoclonal Antibody; Rabbit anti Mouse SERPINA6 Monoclonal Antibody; anti-SERPINA6 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 405

• Applicable Applications for anti-SERPINA6 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse SerpinA6. The detection limit for Mouse SerpinA6 is approximately 0.00245 ng/well.
• Immunogen: Recombinant Mouse SerpinA6 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-SERPINA6  antibody

Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.

NCBI and Uniprot Product Information

• NCBI GI #: 823672932
• NCBI GeneID: 866
• Molecular Weight: 45,141 Da
• NCBI Official Full Name: SERPINA6, partial
• NCBI Official Synonym Full Names: serpin family A member 6
• NCBI Official Symbol: SERPINA6
• NCBI Official Synonym Symbols: CBG
• NCBI Protein Information: corticosteroid-binding globulin
• UniProt Protein Name: Corticosteroid-binding globulin
• UniProt Gene Name: SERPINA6
• UniProt Synonym Gene Names: CBG; CBG
• UniProt Entry Name: CBG_HUMAN

NCBI Description

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]

Uniprot Description

SERPINA6: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency). CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: extracellular space

Molecular Function: serine-type endopeptidase inhibitor activity; steroid binding

Disease: Corticosteroid-binding Globulin Deficiency