Mouse anti-Human S100A7 Monoclonal Antibody | anti-S100A7 antibody

S100A7, Human, mAb 9F3

Cat. Num. AAA584816

• Gene Names: S100A7; PSOR1; S100A7c
• Reactivity: Human
• Applications: Immunohistochemistry, Immunofluorescence, Western Blot
• Synonyms: S100A7; Monoclonal Antibody; Human; mAb 9F3; anti-S100A7 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Form/Format: 1 ml (100 mug/ml) 0.2 mum protein G purified antibody solution in PBS, containing 0.1% bovine serum albumin.; For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)
• Sequence Length: 101

• Applicable Applications for anti-S100A7 antibody: Immunohistochemistry (IHC) Formalin/Paraffin, Immunoassay, Immunofluorescence (IF), Western Blot (WB)
• Application Notes: The typical starting working dilution is 1:50.
• Preparation and Storage: Should be stored at 4 degree C.; Under recommended storage conditions, product is stable for at least one year.

Western Blot (WB)

Immunohistochemistry (IHC)

Related Product Information for anti-S100A7 antibody

Antibody 9F3 recognizes human S100A7 (Psoriasin). S100A7 is a 11.4kDa member of the S100 gene family, which are EF-hand Ca 2+-binding proteins. They are involved in a broad range of intra- and extracellular processes like regulation of calcium homeostasis, cell proliferation, differentiation, apoptosis, immune responses, antimicrobial activity, chemotaxis and inflammation. S100 proteins have a fundamental structural unit which is a highly integrated dimer, some as homodimer and others as heterodimer. S100A7 functions as a homodimer and binds two Zn2+ ions. These ions stabilize the dimer and mediate the function of S100A7 during infection. Extracellular S100A7 functions as a DAMP during infection. S100A7 limits bacterial infection through metal limitation. Furthermore, S100A7 interacts with RAGE which drives an NF-kappaB mediated proinflammatory response and recruitment of neutrophils.
S100A7 was first discovered as a protein abundantly expressed in psoriatic keratinocytes. Possibly, S100A7 adheres directly to, and reduces survival of, pathogens found on the epidermis and acts as a physical barrier. S100A7 also seems to be involved with breast cancer and squamous cell carcinoma. In vitro it was found to confer a more aggressive behavior.

Product Categories/Family for anti-S100A7 antibody

Autoimmunity; Tumor immunology

NCBI and Uniprot Product Information

• NCBI GI #: 49457324
• NCBI GeneID: 6278
• UniProt Accession #: P31151; Q5SY67; Q6FGE3; Q9H1E2
• Molecular Weight: 11,471 Da
• NCBI Official Full Name: S100A7
• NCBI Official Synonym Full Names: S100 calcium binding protein A7
• NCBI Official Symbol: S100A7
• NCBI Official Synonym Symbols: PSOR1; S100A7c
• NCBI Protein Information: protein S100-A7
• UniProt Protein Name: Protein S100-A7
• Protein Family: Protein
• UniProt Gene Name: S100A7
• UniProt Synonym Gene Names: PSOR1; S100A7C

NCBI Description

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]