Mouse ROCK 1 Monoclonal Antibody | anti-ROCK 1 antibody
ROCK 1 antibody
Applications
Western Blot
Purity
ROCK 1 antibody was purified by Protein G purification.
Synonyms
ROCK 1; Monoclonal Antibody; ROCK 1 antibody; Monoclonal ROCK 1; Anti-ROCK 1; ROCK-1; Rho associated coiled coil containing protein kinase 1; anti-ROCK 1 antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG
Clone Number
12M03
Purity/Purification
ROCK 1 antibody was purified by Protein G purification.
Form/Format
Supplied in PBS buffer, pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Concentration
500 ug/ml (varies by lot)
Applicable Applications for anti-ROCK 1 antibody
Western Blot (WB)
Application Notes
WB: 1-4 ug/ml
Biological Significance
ROCK 1 has been found to be a new caspase 3 substrate. ROCK 1 consists of an amino terminal kinase domain and an inhibitory cysteine/histidine rich C terminal domain. During apoptosis, ROCK 1 is cleaved by caspase 3 at the conserved DETD1113/G sequence and its C terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity. The caspase 3 mediated cleavage and activation of ROCK 1 induces phosphorylation of mlC and membrane blebbing, the early events in the execution phase of apoptosis.
Cross-Reactivity
Human, Mouse
Immunogen
ROCK 1 antibody was raised in Mouse using synthetic peptide corresponding to the caspase-3 cleavage site as the immunogen.
Preparation and Storage
Store at -20 degree C. For long-term storage, aliquot and freeze at -70 degree C. Avoid repeated freeze/thaw cycles.
Related Product Information for anti-ROCK 1 antibody
Mouse monoclonal ROCK 1 antibody
Product Categories/Family for anti-ROCK 1 antibody
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Product Notes
The ROCK 1 (Catalog #AAA834700) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's ROCK 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1-4 ug/ml. Researchers should empirically determine the suitability of the ROCK 1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ROCK 1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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