Mouse PTPN7 Monoclonal Antibody | anti-PTPN7 antibody

PTPN7 antibody

Cat. Num. AAA838088

• Gene Names: Ptpn7; LPTP; HEPTP; BPTP-4; LC-PTP; C920001D21Rik
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: PTPN7 antibody was purified by affinity chromatography.
• Synonyms: PTPN7; Monoclonal Antibody; PTPN7 antibody; Monoclonal PTPN7; Anti-PTPN7; Protein tyrosine phosphatase non-receptor type 7; HEPTP; LC-PTP; Hematopoietic protein-tyrosine phosphatase; BPTP4; FLJ18703; LPTP; PTPN 7; PTPN-7; anti-PTPN7 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 3G2
• Purity/Purification: PTPN7 antibody was purified by affinity chromatography.
• Form/Format: Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 500 ug-1 mg/ml (varies by lot)
• Sequence Length: 359

• Applicable Applications for anti-PTPN7 antibody: Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IF: 1:100; IHC: 1:150; WB: 1:2000
• Biological Significance: PTPN7 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitoticcycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigenreceptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinasepathway.
• Cross-Reactivity: Human
• Immunogen: PTPN7 antibody was raised in mouse using a full length recombinant protein of human PTPN7 (NP_542155) produced in HEK293T cells, as the immunogen.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Immunofluorescence (IF)

(Immunofluorescent staining of COS7 cells transiently transfected with recombinant PTPN7 protein using PTPN7 antibody)

Western Blot (WB)

(Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant PTPN7 protein (Right) or empty vector (Left) detected with PTPN7 antibody)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of PTPN7 protein in paraffin embedded Adenocarcinoma of Human ovary tissue using PTPN7 antibody)

Related Product Information for anti-PTPN7 antibody

Mouse monoclonal PTPN7 antibody

Product Categories/Family for anti-PTPN7 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 68534220
• NCBI GeneID: 320139
• Molecular Weight: 40,351 Da
• NCBI Official Full Name: Ptpn7 protein
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, non-receptor type 7
• NCBI Official Symbol: Ptpn7
• NCBI Official Synonym Symbols: LPTP; HEPTP; BPTP-4; LC-PTP; C920001D21Rik
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type 7
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type 7
• Protein Family: Tyrosine-protein phosphatase non-receptor
• UniProt Gene Name: Ptpn7
• UniProt Synonym Gene Names: HEPTP
• UniProt Entry Name: PTN7_MOUSE

Uniprot Description

HePTP: a non-receptor protein-tyrosine phosphatase. Preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. Its noncatalytic N-terminus can interact with MAP kinases and suppress the MAP kinase activities. Shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Three alternatively spliced transcript variants of this gene, which encode two distinct isoforms, are reported. May play a role in the regulation of lymphocyte development.

Protein type: Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.48

Cellular Component: internal side of plasma membrane; cytoskeleton; cytoplasm; cytosol

Molecular Function: hydrolase activity; phosphoric monoester hydrolase activity; protein tyrosine phosphatase activity; phosphoprotein phosphatase activity

Biological Process: dephosphorylation; protein amino acid dephosphorylation