PTPN7 recombinant protein

PTPN7, 1-360aa, Human, His tag, E Coli

Cat. Num. AAA204655

• Gene Names: PTPN7; LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: PTPN7; 1-360aa; Human; His tag; E Coli; Tyrosine-protein phosphatase non-receptor type 7; BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI; PTPN7 recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMVQAHG GRSRAQPLTL SLGAAMTQPP PEKTPAKKHV RLQERRGSNV ALMLDVRSLG AVEPICSVNT PREVTLHFLR TAGHPLTRWA LQRQPPSPKQ LEEEFLKIPS NFVSPEDLDI PGHASKDRYK TILPNPQSRV CLGRAQSQED GDYINANYIR GYDGKEKVYI ATQGPMPNTV SDFWEMVWQE EVSLIVMLTQ LREGKEKCVH YWPTEEETYG PFQIRIQDMK ECPEYTVRQL TIQYQEERRS VKHILFSAWP DHQTPESAGP LLRLVAEVEE SPETAAHPGP IVVHCSAGIG RTGCFIATRI GCQQLKARGE VDILGIVCQL RLDRGGMIQT AEQYQFLHHT LALYAGQLPE EPSP
• Sequence Length: 360

• Applicable Applications for PTPN7 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for PTPN7 recombinant protein

PTPN7, also known as tyrosine-protein phosphatase non-receptor type 7 isoform 1, acts preferentially on tyrosine-phosphorylated MAPK1. This protein plays a role in the regulation of T and B-lymphocyte development and signal transduction. Recombinant human PTPN7 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.

Product Categories/Family for PTPN7 recombinant protein

Enzymes & Proteases

References

Pettiford S.M., et al. (2000) Oncogene. 19:858-869; Nika K., et al. (2004) Biochem. J. 378:335-342;

NCBI and Uniprot Product Information

• NCBI GI #: 18375658
• NCBI GeneID: 5778
• NCBI Accession #: NP_002823.2
• NCBI GenBank Nucleotide #: NM_002832.2
• Molecular Weight: 43.1 kDa (384aa), confirmed by MALDI-TOF
• NCBI Official Full Name: tyrosine-protein phosphatase non-receptor type 7 isoform 1
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, non-receptor type 7
• NCBI Official Symbol: PTPN7
• NCBI Official Synonym Symbols: LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type 7
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type 7
• Protein Family: Tyrosine-protein phosphatase non-receptor
• UniProt Gene Name: PTPN7
• UniProt Synonym Gene Names: HEPTP

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]

Uniprot Description

Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.