Mouse anti-Human PTEN Monoclonal Antibody | anti-PTEN antibody
PTEN Monoclonal Antibody
NCBI and Uniprot Product Information
NCBI Description
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Uniprot Description
PTEN: a phosphoinositide 3-phosphatase (PIP3) and a tumor suppressor implicated in a wide variety of human cancers. Dephosphorylates inositol phospholipids generated by the activation of the phosphoinositide 3 kinase (PI3K). A major negative regulator of the PI3K/Akt signaling pathway. Possesses a C-terminal regulatory domain that contains three phosphorylation sites which may regulate its stability.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Phosphatase, lipid; Tumor suppressor
Chromosomal Location of Human Ortholog: 10q23.31
Cellular Component: apical plasma membrane; cell projection; cytoplasm; cytoplasmic side of plasma membrane; cytosol; dendritic spine; extracellular region; mitochondrion; neuron projection; nucleoplasm; nucleus; plasma membrane; PML body; postsynaptic membrane
Molecular Function: anaphase-promoting complex binding; enzyme binding; identical protein binding; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; ionotropic glutamate receptor binding; lipid binding; magnesium ion binding; PDZ domain binding; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphoprotein phosphatase activity; platelet-derived growth factor receptor binding; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; ubiquitin-specific protease binding
Biological Process: adult behavior; aging; angiogenesis; apoptosis; brain morphogenesis; cardiac muscle tissue development; cell migration; cell proliferation; cellular response to ethanol; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to insulin-like growth factor stimulus; cellular response to leptin stimulus; central nervous system development; central nervous system myelin maintenance; central nervous system neuron axonogenesis; dentate gyrus development; endothelial cell migration; forebrain morphogenesis; heart development; inositol phosphate dephosphorylation; inositol phosphate metabolic process; learning and/or memory; locomotor rhythm; locomotory behavior; male mating behavior; maternal behavior; memory; multicellular organismal response to stress; negative regulation of apoptosis; negative regulation of axon regeneration; negative regulation of axonogenesis; negative regulation of cardiac muscle cell proliferation; negative regulation of cell aging; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; negative regulation of epithelial cell proliferation; negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of excitatory postsynaptic potential; negative regulation of focal adhesion assembly; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of keratinocyte migration; negative regulation of myelination; negative regulation of organ growth; negative regulation of phagocytosis; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of potassium ion transmembrane transporter activity; negative regulation of protein kinase B signaling cascade; negative regulation of protein phosphorylation; negative regulation of receptor activity; negative regulation of ribosome biogenesis; negative regulation of synaptic vesicle clustering; nerve-nerve synaptic transmission; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of excitatory postsynaptic potential; positive regulation of gene expression; positive regulation of neuron differentiation; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; positive regulation of TRAIL-activated apoptotic signaling pathway; positive regulation of transcription factor activity; positive regulation of ubiquitin protein ligase activity; prepulse inhibition; protein amino acid dephosphorylation; protein deubiquitination; protein kinase B signaling; protein stabilization; regulation of B cell apoptotic process; regulation of cellular component size; regulation of cyclin-dependent protein kinase activity; regulation of myeloid cell apoptosis; regulation of neuron projection development; regulation of protein stability; regulation of synaptic transmission, GABAergic; response to activity; response to arsenic; response to ATP; response to drug; response to estradiol; response to glucose stimulus; response to nutrient; response to zinc ion; rhythmic synaptic transmission; social behavior; synapse maturation; synaptogenesis; Wnt receptor signaling pathway through beta-catenin
Disease: Bannayan-riley-ruvalcaba Syndrome; Cowden Syndrome 1; Endometrial Cancer; Glioma Susceptibility 2; Macrocephaly/autism Syndrome; Melanoma, Cutaneous Malignant, Susceptibility To, 1; Meningioma, Familial, Susceptibility To; Prostate Cancer; Squamous Cell Carcinoma, Head And Neck; Thyroid Carcinoma, Follicular; Vacterl Association With Hydrocephalus
Research Articles on PTEN
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Product Notes
The PTEN pten (Catalog #AAA2549003) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The PTEN Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PTEN can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin (IHC-p). IHC: 1:100-200. Researchers should empirically determine the suitability of the PTEN pten for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTEN, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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