Mouse PSD95 Monoclonal Antibody | anti-DLG4 antibody

Anti-PSD95 Monoclonal Antibody

Cat. Num. AAA190489

• Gene Names: DLG4; PSD95; SAP90; SAP-90; FLJ97752; FLJ98574
• Applications: Immunoblot, Western Blot, Immunocytochemistry
• Synonyms: PSD95; Monoclonal Antibody; Anti-PSD95 Monoclonal Antibody; anti-DLG4 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2a
• Specificity: PSD95 [Mouse monoclonal antibody recognizes mouse, rat, and bovine PSD95.]; This antibody recognizes mouse, rat, and bovine PSD95.
• Form/Format: 100ug in PBS, pH 7.4, purified by Protein G affinity chromatography.

• Applicable Applications for anti-DLG4 antibody: Immunoblot, Immunocytochemistry
• Application Notes: Immunoblotting: use at 4ug/ml. A band of ~100 kDa is detected.; Immunocytochemistry: use at 3-15ug/ml These are recommended concentrations. User should determine optimal concentrations for their application.; Positive control: Rat brain tissue
• Antigen: Recombinant rat PSD95
• Preservatives: 0.09% sodium azide
• Other Additives: 50% glycerol
• Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
• Preparation and Storage: This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.

Related Product Information for anti-DLG4 antibody

Postsynaptic Density Protein 95 (PSD95), also known as Synapse Associated Protein 90kDa, is a member of the membrane-associated guanylate kinase family of proteins. PSD95 is a scaffolding protein involved in the assembly and function of the postsynaptic density complex. This family of proteins consists of N-terminal variable segments followed by three amino-terminal PDZ domains, an upstream SH3 domain, and an inactive carboxy-terminal guanylate kinase domain. The first and second PDZ domains localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins, neuronal cell adhesion molecules. PSD95 also binds to neuronal nitric oxide synthase. PSD95 is implicated in experience-dependent plasticity and plays an indispensable role in learning. Mutations in PSD95 are associated with autism.

Product Categories/Family for anti-DLG4 antibody

Neuroscience and Signal Transduction Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 3318653
• NCBI GeneID: 1742
• UniProt Accession #: O14909; P78352; Q3ZCU5
• Molecular Weight: 31,914 Da
• NCBI Official Full Name: post-synaptic density protein 95
• NCBI Official Synonym Full Names: discs, large homolog 4 (Drosophila)
• NCBI Official Symbol: DLG4
• NCBI Official Synonym Symbols: PSD95; SAP90; SAP-90; FLJ97752; FLJ98574
• NCBI Protein Information: disks large homolog 4; OTTHUMP00000166066; OTTHUMP00000166067; OTTHUMP00000166068; discs large homolog 4; Tax interaction protein 15; synapse-associated protein 90; postsynaptic density protein 95; post-synaptic density protein 95
• UniProt Protein Name: Discs, large homolog 4 (Drosophila), isoform CRA_d
• Protein Family: Disks large
• UniProt Gene Name: DLG4
• UniProt Entry Name: O14909_HUMAN

NCBI Description

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]