Mouse anti-Human PROZ Monoclonal Antibody | anti-PROZ antibody

Anti-PROZ Mouse mAb

Cat. Num. AAA475934

• Gene Names: PROZ; PZ
• Reactivity: Human
• Applications: Western Blot
• Synonyms: PROZ; Monoclonal Antibody; Anti-PROZ Mouse mAb; protein Z; PZ; anti-PROZ antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 2B4
• Form/Format: Ascitic fluid containing 0.03% sodium azide.
• Sequence Length: 400

• Applicable Applications for anti-PROZ antibody: Western Blot (WB)
• Immunogen: Purified recombinant fragment of PROZ expressed in E Coli.

Western Blot (WB)

(Western blot analysis using PROZ mouse mAb against human plasma (1).)

Related Product Information for anti-PROZ antibody

Entrez Summary: PROZ protein Z, vitamin K-dependent plasma glycoprotein. It is 62 kDa large and 396 amino acids long. It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain. It lacks the serine residue that would make it catalytically active as a serine protease. It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces. The main role of protein Z appears to be the degradation of factor Xa. This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z. In some studies, deficiency states have been associated with a propensity to thrombosis. Others, however, link it to bleeding tendency; there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.

NCBI and Uniprot Product Information

• NCBI GI #: 823674522
• NCBI GeneID: 8858
• Molecular Weight: 45
• NCBI Official Full Name: PROZ, partial
• NCBI Official Synonym Full Names: protein Z, vitamin K dependent plasma glycoprotein
• NCBI Official Symbol: PROZ
• NCBI Official Synonym Symbols: PZ
• NCBI Protein Information: vitamin K-dependent protein Z
• UniProt Protein Name: Vitamin K-dependent protein Z
• Protein Family: Vitamin K-dependent protein
• UniProt Gene Name: PROZ

NCBI Description

This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Description

PROZ: Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: endoplasmic reticulum lumen; extracellular space; Golgi lumen

Biological Process: blood coagulation; ER to Golgi vesicle-mediated transport; peptidyl-glutamic acid carboxylation; signal peptide processing

Disease: Protein Z Deficiency