Dilution Information
Mouse anti-Human PLAP Monoclonal Antibody | anti-PLAP antibody
PLAP
Gene Names
Plaa; Plap; PLA2P
Reactivity
Human
Applications
Immunohistochemistry
Synonyms
PLAP; Monoclonal Antibody; anti-PLAP antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Form/Format
PLAP is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Sequence Length
351
Applicable Applications for anti-PLAP antibody
Immunohistochemistry (IHC) Formalin/Paraffin
Localization
Cytoplasmic
Control
Placenta
Intended Use
This antibody is intended for use in Immunohistochemical applications on formalinfixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations. Interpretation of results should be performed by a qualified medical professional.
* The PLAP antibody, clone EP194, has been manufactured using Epitomics RabMab technology covered under Patent No.'s 5,675,063 and 7,402,409.
* The PLAP antibody, clone EP194, has been manufactured using Epitomics RabMab technology covered under Patent No.'s 5,675,063 and 7,402,409.
Immunogen
A synthetic peptide corresponding to residues of human PLAP protein.
Preparation and Storage
Store at 2 to 8 degree C in the dark.
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(IHC of PLAP on an FFPE Placenta Tissue)
Immunohistochemistry (IHC)
(IHC of PLAP on an FFPE Placenta Tissue)
Related Product Information for anti-PLAP antibody
Alkaline phosphatase, placental type also known as placental alkaline phosphatase (PLAP) is an allosteric enzyme that in humans is encoded by the ALPP gene. PLAP is found in trophoblast cells of normal mature human placenta, Seminomas of testis and Ovarian Carcinomas. Detection of alkaline phosphatase in serum is a marker for Ovarian and Testicular Cancer.
This antibody reacts with a membrane-bound isoenzyme of placental alkaline phosphatase occurring in the placenta during the 3rd trimester of gestation.
This antibody immunoreacts with Germ Cell Tumors and can discriminate between these and other neoplasms. Somatic neoplasms (e.g., breast, gastrointestinal, prostatic and urinary cancers) may also immunoreact with antibodies to PLAP. PLAP positivity, in conjunction with keratin negativity, favors Seminoma over Carcinoma. Germ Cell Tumors are usually keratin positive but they regularly fail to stain with EMA, whereas most Carcinomas stain with anti-EMA. This antibody has shown cross-reaction with human intestinal alkaline phosphatase.
This antibody reacts with a membrane-bound isoenzyme of placental alkaline phosphatase occurring in the placenta during the 3rd trimester of gestation.
This antibody immunoreacts with Germ Cell Tumors and can discriminate between these and other neoplasms. Somatic neoplasms (e.g., breast, gastrointestinal, prostatic and urinary cancers) may also immunoreact with antibodies to PLAP. PLAP positivity, in conjunction with keratin negativity, favors Seminoma over Carcinoma. Germ Cell Tumors are usually keratin positive but they regularly fail to stain with EMA, whereas most Carcinomas stain with anti-EMA. This antibody has shown cross-reaction with human intestinal alkaline phosphatase.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
87,084 Da
NCBI Official Full Name
PLAP
NCBI Official Synonym Full Names
phospholipase A2, activating protein
NCBI Official Symbol
Plaa
NCBI Official Synonym Symbols
Plap; PLA2P
NCBI Protein Information
phospholipase A-2-activating protein
UniProt Protein Name
Phospholipase A-2-activating protein
Protein Family
UniProt Gene Name
Plaa
UniProt Synonym Gene Names
Plap; PLA2P; PLAP
UniProt Entry Name
PLAP_RAT
NCBI Description
may play a role in phospholipase activation, production of prostaglandins, and regulation of inflammatory response [RGD, Feb 2006]
Uniprot Description
PLAA: phospholipase A2 activating protein. A regulator of the production of eicosanoids and prostaglandin E(2) in immune and inflammatory responses. Belongs to the WD repeat PLAP family.
Protein type: Activator
Molecular Function: phospholipase A2 activator activity
Biological Process: inflammatory response; positive regulation of catalytic activity
Research Articles on PLAP
Similar Products
Product Notes
The PLAP plaa (Catalog #AAA370319) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The PLAP reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PLAP can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Formalin/Paraffin. Researchers should empirically determine the suitability of the PLAP plaa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLAP, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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