Rabbit anti-Human HER-3/c-erbB-3 Monoclonal Antibody | anti-HER-3/c-erbB-3 antibody
HER-3/c-erbB-3 RMab
Reactivity
Human
Applications
Immunohistochemistry
Synonyms
HER-3/c-erbB-3; Monoclonal Antibody; HER-3/c-erbB-3 RMab; anti-HER-3/c-erbB-3 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
RBT-HER3
Form/Format
HER-3 is a rabbit monoclonal antibody derived from cell culture supernatant thatis concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Applicable Applications for anti-HER-3/c-erbB-3 antibody
Immunohistochemistry (IHC) Formalin/Paraffin
Localization
Membranous
Control
Colon, Cervix, Bladder TCC
Intended Use
This antibody is intended for use in Immunohistochemical applications on formalinfixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations. Interpretation of results should be performed by a qualified medical professional.
Immunogen
A synthetic peptide corresponding to human c-erb-3 (HER-3) protein.
Preparation and Storage
Store at 2 to 8 degree C in the dark.
Dilution Information
Immunohistochemistry (IHC)
(IHC of HER-3 on an FFPE Colon Tissue)
Related Product Information for anti-HER-3/c-erbB-3 antibody
Receptor tyrosine-protein kinase erbB-3, also known as HER-3 (Human Epidermal Growth Factor Receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. HER-3 has been shown to bind the ligands heregulin and NRG-2. Ligand binding causes a change in conformation that allows for dimerization, phosphorylation, and activation of signal transduction. HER-3 can heterodimerize with any of the other three ErbB family members.
During human development, HER-3 is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium and is expressed in normal adult human gastrointestinal tract, reproductive system, skin, nervous system, urinary tract, and endocrine system. HER-3 is overexpressed in a variety of tumors including breast, stomach, pancreas, and colon. While no evidence has been found that HER-3 overexpression, constitutive activation, or mutation alone is oncogenic, the protein as a heterodimerization partner, most critically with HER-2, is implicated in growth, proliferation, resistance, and the promotion of invasion and metastasis.
During human development, HER-3 is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium and is expressed in normal adult human gastrointestinal tract, reproductive system, skin, nervous system, urinary tract, and endocrine system. HER-3 is overexpressed in a variety of tumors including breast, stomach, pancreas, and colon. While no evidence has been found that HER-3 overexpression, constitutive activation, or mutation alone is oncogenic, the protein as a heterodimerization partner, most critically with HER-2, is implicated in growth, proliferation, resistance, and the promotion of invasion and metastasis.
