Dilution Information
Rabbit anti-Human HER-3/c-erbB-3 Monoclonal Antibody | anti-HER-3/c-erbB-3 antibody
HER-3/c-erbB-3 RMab
Reactivity
Human
Applications
Immunohistochemistry
Synonyms
HER-3/c-erbB-3; Monoclonal Antibody; HER-3/c-erbB-3 RMab; anti-HER-3/c-erbB-3 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
RBT-HER3
Form/Format
HER-3 is a rabbit monoclonal antibody derived from cell culture supernatant thatis concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Applicable Applications for anti-HER-3/c-erbB-3 antibody
Immunohistochemistry (IHC) Formalin/Paraffin
Localization
Membranous
Control
Colon, Cervix, Bladder TCC
Intended Use
This antibody is intended for use in Immunohistochemical applications on formalinfixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations. Interpretation of results should be performed by a qualified medical professional.
Immunogen
A synthetic peptide corresponding to human c-erb-3 (HER-3) protein.
Preparation and Storage
Store at 2 to 8 degree C in the dark.
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(IHC of HER-3 on an FFPE Colon Tissue)
Immunohistochemistry (IHC)
(IHC of HER-3 on an FFPE Colon Tissue)
Related Product Information for anti-HER-3/c-erbB-3 antibody
Receptor tyrosine-protein kinase erbB-3, also known as HER-3 (Human Epidermal Growth Factor Receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. HER-3 has been shown to bind the ligands heregulin and NRG-2. Ligand binding causes a change in conformation that allows for dimerization, phosphorylation, and activation of signal transduction. HER-3 can heterodimerize with any of the other three ErbB family members.
During human development, HER-3 is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium and is expressed in normal adult human gastrointestinal tract, reproductive system, skin, nervous system, urinary tract, and endocrine system. HER-3 is overexpressed in a variety of tumors including breast, stomach, pancreas, and colon. While no evidence has been found that HER-3 overexpression, constitutive activation, or mutation alone is oncogenic, the protein as a heterodimerization partner, most critically with HER-2, is implicated in growth, proliferation, resistance, and the promotion of invasion and metastasis.
During human development, HER-3 is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium and is expressed in normal adult human gastrointestinal tract, reproductive system, skin, nervous system, urinary tract, and endocrine system. HER-3 is overexpressed in a variety of tumors including breast, stomach, pancreas, and colon. While no evidence has been found that HER-3 overexpression, constitutive activation, or mutation alone is oncogenic, the protein as a heterodimerization partner, most critically with HER-2, is implicated in growth, proliferation, resistance, and the promotion of invasion and metastasis.
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Product Notes
The HER-3/c-erbB-3 (Catalog #AAA370306) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HER-3/c-erbB-3 RMab reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HER-3/c-erbB-3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Formalin/Paraffin. Researchers should empirically determine the suitability of the HER-3/c-erbB-3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HER-3/c-erbB-3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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