Western Blot (WB)
(Western Blot analysis of ROS1728 cells using PLAA Monoclonal Antibody at dilution of 1:1000)
Mouse PLAA Monoclonal Antibody | anti-PLAA antibody
PLAA Monoclonal Antibody
Gene Names
PLAA; DOA1; PLAP; PLA2P; NDMSBA
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, ELISA
Purity
Protein A purification
Synonyms
PLAA; Monoclonal Antibody; PLAA Monoclonal Antibody; FLJ11281; FLJ12699; Glycerophosphatase; OTTHUMP00000045176; Phospholipase A 2 activating protein; Phospholipase A-2-activating protein; Phospholipase A2 activating protein; PLA2P; Plaa; PLAP; anti-PLAA antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
555
Purity/Purification
Protein A purification
Concentration
1mg/mL (varies by lot)
Sequence Length
795
Applicable Applications for anti-PLAA antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes
WB: 1:500-1:5000
IHC: 1:50-1:500
IHC: 1:50-1:500
Immunogen
Fusion protein of PLAA
Buffer
PBS with 0.02% sodium azide, 50% glycerol, PH7.3
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Western Blot (WB)
(Western Blot analysis of ROS1728 cells using PLAA Monoclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of ROS1728 cells using PLAA Monoclonal Antibody at dilution of 1:1000)
Related Product Information for anti-PLAA antibody
Phospholipase A-2-activating protein (PLAA), also named PLAP, can interact with ubiquitin and is involved in the maintenance of ubiquitin levels. PLAA contains multiple consensus domains including WD repeats, PFU domain and PUL domain. Although the function of PLAA remains unclear, ubiquitin binding of PLAA might be the central role that connects ubiquitination and degradation in ERAD. Recent finding revealed that PLAA served as a novel nociveptive mediator after incision, and its expression level is regulated by miR-203.
Product Categories/Family for anti-PLAA antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Calculated: 81kDa
Observed: 72-74kDa
Observed: 72-74kDa
NCBI Official Full Name
phospholipase A-2-activating protein isoform 1
NCBI Official Synonym Full Names
phospholipase A2 activating protein
NCBI Official Symbol
PLAA
NCBI Official Synonym Symbols
DOA1; PLAP; PLA2P; NDMSBA
NCBI Protein Information
phospholipase A-2-activating protein
UniProt Protein Name
Phospholipase A-2-activating protein
Protein Family
UniProt Gene Name
PLAA
UniProt Synonym Gene Names
PLAP; PLA2P; PLAP
Uniprot Description
Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986).
Research Articles on PLAA
Similar Products
Product Notes
The PLAA plaa (Catalog #AAA2542029) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The PLAA Monoclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PLAA can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). WB: 1:500-1:5000 IHC: 1:50-1:500. Researchers should empirically determine the suitability of the PLAA plaa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLAA, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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