Western Blot (WB)
Rabbit anti-Mouse CD105 / Endoglin Polyclonal Antibody | anti-CD105 / Endoglin antibody
Anti-CD105 / Endoglin antibody
Reactivity
Mouse
Applications
Western Blot
Purity
Immunogen affinity purified
Synonyms
CD105 / Endoglin; Polyclonal Antibody; Anti-CD105 / Endoglin antibody; Polyclonal Anti- CD105 / Endoglin; anti-CD105 / Endoglin antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified
Form/Format
Liquid
Applicable Applications for anti-CD105 / Endoglin antibody
Western Blot (WB)
Application Notes
WB (1:500)
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to the extracellular region of mouse CD105.
Storage Buffer
In TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide
Storage Buffer
In TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.
Preparation and Storage
Store at 4 degree C after thawing (1 week). Aliquot and store at -20 degree C for long term (at least one year). Avoid repeated freeze and thaw cycles
Western Blot (WB)
Western Blot (WB)
Related Product Information for anti-CD105 / Endoglin antibody
Endoglin (CD105) is a cell surface component of the transforming growth factor-beta (TGF-beta) receptor complex highly expressed by endothelial cells. It may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. Mutations in the endoglin gene are responsible for the hereditary hemorrhagic telangiectasia type 1 (HHT1), also known as Osler-Weber-Rendu syndrome.1 This gene also plays an important role in cardiovascular development and vascular remodeling.2 Endoglin levels have been found to be elevated in pregnant women who subsequently develop preeclampsia.3
References
1. Rius, C., Smith, J. D., Almendro, N., Langa, C., Botella, L. M., Marchuk, D. A., Vary, C. P. H., Bernabeu, C. Cloning of the promoter region of human endoglin, the target gene for hereditary hemorrhagic telangiectasia type 1. Blood 92: 4677-4690, 1998. 2. Sanz-Rodriguez, Francisco; Mercedes Guerrero-Esteo, Luisa-Maria Botella, Denis Banville (2004). "Endoglin Regulates Cytoskeletal Organization through Binding to ZRP-1, a Member of the Lim Family of Proteins". J. Biol. Chem. 279 (31): 32858-68. 3. Venkatesha, S; Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA, Stillman IE, Roberts D, D'Amore PA, Epstein FH, Sellke FW, Romero R, Sukhatme VP, Letarte M, Karumanchi SA. (2006). "Soluble endoglin contributes to the pathogenesis of preeclampsia". Nat Med 12 (6): 642-9.
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Product Notes
The CD105 / Endoglin (Catalog #AAA355054) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CD105 / Endoglin antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD105 / Endoglin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB (1:500). Researchers should empirically determine the suitability of the CD105 / Endoglin for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD105 / Endoglin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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