Dilution Information
()
Mouse PLA2R1 Monoclonal Antibody | anti-PLA2R1 antibody
PLA2R1, Mmab
Gene Names
PLA2R1; PLA2R; PLA2-R; PLA2IR; CLEC13C; PLA2G1R
Applications
Immunohistochemistry
Synonyms
PLA2R1; Monoclonal Antibody; Mmab; anti-PLA2R1 antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
BSB-129
Form/Format
Concentrate or Prediluted
Sequence Length
1461
Applicable Applications for anti-PLA2R1 antibody
Immunohistochemistry (IHC) Frozen/Paraffin
Immunogen
Recombinant fragment corresponding to residues of the human phospholipase A2 receptor 1, protein.
Localization
Cytoplasmic, Membranous
Control
Brain, Testis, Kidney, Salivary Gland, Gastic GIST
Intended Use
This antibody is intended for use in Immunohistochemical applications on formalinfixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations. Interpretation of results should be performed by aqualified medical professional.
Preparation and Storage
Store at 2-8 degree C.
Dilution Information
()
Dilution Information
()
Immunohistochemistry (IHC)
(IHC PLA2R1 on a FFPE Kidney Tissue)
Immunohistochemistry (IHC)
(IHC PLA2R1 on a FFPE Kidney Tissue)
Related Product Information for anti-PLA2R1 antibody
PLA2R1 gene encodes phospholipase A2 receptor 1 protein, a 180 kDa transmembrane glycoproteins expressed by podocyte. Approximately 70% of patients with idiopathic membranous glomerulopathy have autoantibodies directed against podocyte PLA2R1. PLA2R1 also promotes tumor suppressive responses including senescence, apoptosis, and inhibition of transformation. Known oncogenes such as HIF2alpha and c-Myc repress PLA2R1 expression.
PLA2R1 gain or loss of function experiments in vitro and in vivo shows that this receptor promotes several tumor suppressive responses including senescence, apoptosis and inhibition of transformation. Supporting a tumor suppressive role of PLA2R1, its expression decreases in numerous cancers, and known oncogenes such as HIF2alpha and c-MYC repress its expression. PLA2R1 promoter methylation, a classical way to repress tumor suppressive gene expression in cancer cells, is observed in leukemia, in kidney and in breast cancer cells. Mechanistically, PLA2R1 activates the kinase JAK2 and orients its activity towards a tumor suppressive one. PLA2R1 also promotes accumulation of reactive oxygen species which induce cell death and senescence. This review compiles recent data demonstrating an unexpected tumor suppressive role of PLA2R1 and outlines the future work needed to improve our knowledge of the functions of this gene in cancer.
PLA2R1 gain or loss of function experiments in vitro and in vivo shows that this receptor promotes several tumor suppressive responses including senescence, apoptosis and inhibition of transformation. Supporting a tumor suppressive role of PLA2R1, its expression decreases in numerous cancers, and known oncogenes such as HIF2alpha and c-MYC repress its expression. PLA2R1 promoter methylation, a classical way to repress tumor suppressive gene expression in cancer cells, is observed in leukemia, in kidney and in breast cancer cells. Mechanistically, PLA2R1 activates the kinase JAK2 and orients its activity towards a tumor suppressive one. PLA2R1 also promotes accumulation of reactive oxygen species which induce cell death and senescence. This review compiles recent data demonstrating an unexpected tumor suppressive role of PLA2R1 and outlines the future work needed to improve our knowledge of the functions of this gene in cancer.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
PLA2R1 protein
NCBI Official Synonym Full Names
phospholipase A2 receptor 1
NCBI Official Symbol
PLA2R1
NCBI Official Synonym Symbols
PLA2R; PLA2-R; PLA2IR; CLEC13C; PLA2G1R
NCBI Protein Information
secretory phospholipase A2 receptor
Protein Family
NCBI Description
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Research Articles on PLA2R1
Similar Products
Product Notes
The PLA2R1 (Catalog #AAA370380) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PLA2R1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Frozen/Paraffin. Researchers should empirically determine the suitability of the PLA2R1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLA2R1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
