Rabbit anti-Mouse PLA2G1B Monoclonal Antibody | anti-PLA2G1B antibody
Recombinant Anti-PLA2G1B Antibody, Rabbit Monoclonal
Gene Names
Pla2g1b; Pla2a; sPLA2IB
Reactivity
Mouse
Applications
ELISA
Purity
Protein A
Synonyms
PLA2G1B; Monoclonal Antibody; Recombinant Anti-PLA2G1B Antibody; Rabbit Monoclonal; PLA2G1B Antibody; Rabbit MAb; phospholipase A2; group IB (pancreas); Anti-Pla2a Antibody; Anti-sPLA2IB Antibody; anti-PLA2G1B antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
004
Specificity
Mouse PLA2G1B
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-PLA2G1B antibody
ELISA (EIA) (Det)
Application Notes
ELISA (Det): This antibody will detect Mouse PLA2G1B in ELISA pair set.
In a sandwich ELISA, it can be used as detection antibody when paired with.
In a sandwich ELISA, it can be used as detection antibody when paired with.
Antibody Type
Recombinant Antibody
Immunogen
Recombinant Mouse PLA2G1B Protein
Conjugation
Unconjugated
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PLA2G1B (rM PLA2G1B).
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-PLA2G1B antibody
phospholipase A2, also known as Phosphatidylcholine 2-acylhydrolase 1B, Group IB phospholipase A2, PLA2 and PLA2G1B, is a secreted protein that belongs to the phospholipase A2 family. Phospholipase A2/PLA2G1B catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic Phospholipase A2/PLA2G1B enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of Phospholipase A2/PLA2G1B have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets. Mice lacking in Phospholipase A2/PLA2G1B are resistant to obesity and diabetes induced by feeding a diabetogenic high-fat/high-carbohydrate diet. Oral supplementation of a diabetogenic diet with the PLA2G1B inhibitor methyl indoxam effectively suppresses diet-induced obesity and diabetes. PLA2G1B inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes.
References
Labonte, E.D. et al., 2006, Diabetes. 55 (4) :935-41. Mounier, C.M. et al., 2008, Br J Cancer. 98 (3):587-95. Hui, D.Y. et al., 2009, Br J Pharmacol. 157 (7):1263-9. Labonte, E.D. et al., 2010, FASEB J. 24 (7):2516-24.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
16,290 Da
NCBI Official Full Name
phospholipase A2
NCBI Official Synonym Full Names
phospholipase A2, group IB, pancreas
NCBI Official Symbol
Pla2g1b
NCBI Official Synonym Symbols
Pla2a; sPLA2IB
NCBI Protein Information
phospholipase A2
UniProt Protein Name
Phospholipase A2
Protein Family
UniProt Gene Name
Pla2g1b
UniProt Synonym Gene Names
Pla2
UniProt Entry Name
PA21B_MOUSE
Uniprot Description
PLA2G1B: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Belongs to the phospholipase A2 family.
Protein type: DNA replication; Lipid Metabolism - arachidonic acid; EC 3.1.1.4; Phospholipase; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Secreted; Secreted, signal peptide; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - ether lipid
Cellular Component: cell surface; extracellular region; extracellular space; secretory granule
Molecular Function: calcium ion binding; calcium-dependent phospholipase A2 activity; hydrolase activity; metal ion binding; phospholipase A2 activity; receptor binding
Biological Process: antibacterial humoral response; defense response to Gram-positive bacterium; fatty acid biosynthetic process; innate immune response in mucosa; lipid catabolic process; lipid metabolic process; multicellular organismal lipid catabolic process; phosphatidylcholine metabolic process; phospholipid catabolic process; phospholipid metabolic process; positive regulation of DNA replication
Research Articles on PLA2G1B
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Product Notes
The PLA2G1B pla2g1b (Catalog #AAA8111399) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Anti-PLA2G1B Antibody, Rabbit Monoclonal reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PLA2G1B can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA) (Det). ELISA (Det): This antibody will detect Mouse PLA2G1B in ELISA pair set. In a sandwich ELISA, it can be used as detection antibody when paired with. Researchers should empirically determine the suitability of the PLA2G1B pla2g1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLA2G1B, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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