Testing Data
(Image: Mouse brain section, which was cut at 45muM on a vibratome after perfusion with 4% parformaldehyde and overnight fixation, was stained with monoclonal antibody at 1: 1,000: Phospho-MeCP2 at S421 was mainly associated with methylated DNA in nucleus of activated neuron cells (red). Blue shows DAPI staining of nuclear DNA.)
anti-Mouse Phospho-MeCP2 Monoclonal Antibody
Phospho-MeCP2, monoclonal antibody, mouse
Reactivity
Mouse
Applications
Immunocytochemistry, Immunofluorescence, Immunohistochemistry
Purity
Affinity Purified
Synonyms
Phospho-MeCP2; Monoclonal Antibody; monoclonal antibody; mouse; anti-Phospho-MeCP2 antibody
Reactivity
Mouse
Clonality
Monoclonal
Purity/Purification
Affinity Purified
Form/Format
Liquid
Applicable Applications for anti-Phospho-MeCP2 antibody
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC)
Testing Data
(Image: Mouse brain section, which was cut at 45muM on a vibratome after perfusion with 4% parformaldehyde and overnight fixation, was stained with monoclonal antibody at 1: 1,000: Phospho-MeCP2 at S421 was mainly associated with methylated DNA in nucleus of activated neuron cells (red). Blue shows DAPI staining of nuclear DNA.)
Testing Data
(Image: Mouse brain section, which was cut at 45muM on a vibratome after perfusion with 4% parformaldehyde and overnight fixation, was stained with monoclonal antibody at 1: 1,000: Phospho-MeCP2 at S421 was mainly associated with methylated DNA in nucleus of activated neuron cells (red). Blue shows DAPI staining of nuclear DNA.)
Related Product Information for anti-Phospho-MeCP2 antibody
Methyl-CpG Binding Protein 2 (MeCP2) is a nuclear protein that is found to bind to symmetrical methylated CpG dinucleotide sequences. It is a transcriptional modulator that can alter gene expression epigenetically via binding to methylated DNA. It is involved not only in transcriptional silencing, but also in transcriptional activation, chromatin remodeling, and RNA splicing. Mecp2is a X-chromosome-linked gene, highly expressed in neurons. The mutations of Mecp2 are linked to Rett syndrome (RTT), which is a neurodevelopmental, autistic disorder that affects mainly females. Studies show that even the loss of a specific phosphorylation site of MeCP2 (e.g., S80, S421, and S424) disturbs normal maturation of the mammalian brain.
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Product Notes
The Phospho-MeCP2 (Catalog #AAA555675) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Phospho-MeCP2, monoclonal antibody, mouse reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Phospho-MeCP2 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the Phospho-MeCP2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phospho-MeCP2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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