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Mouse anti-Human PGRP-L Monoclonal Antibody | anti-PGLYRP2 antibody

PGRP-L (N-acetylmuramoyl-L-alanine Amidase, Peptidoglycan Recognition Protein 2, Peptidoglycan Recognition Protein Long, PGLYRP2, PGLYRPL, PGRPL, UNQ3103/PRO10102)

Gene Names
PGLYRP2; tagL; PGRPL; PGRP-L; PGLYRPL; HMFT0141; TAGL-like; tagl-beta; tagL-alpha
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Ascites
Ascites
Synonyms
PGRP-L; Monoclonal Antibody; PGRP-L (N-acetylmuramoyl-L-alanine Amidase; Peptidoglycan Recognition Protein 2; Peptidoglycan Recognition Protein Long; PGLYRP2; PGLYRPL; PGRPL; UNQ3103/PRO10102); Anti -PGRP-L (N-acetylmuramoyl-L-alanine Amidase; anti-PGLYRP2 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1, k
Clone Number
10K303
Specificity
Recognizes human PGRP-L.
Purity/Purification
Ascites
Ascites
Form/Format
Supplied as a liquid in PBS, 50% glycerol.
Applicable Applications for anti-PGLYRP2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:2,000
Immunogen
Peptidoglycan recognition protein (PGRP)-L purified from human protein.
Positive Control
Human plasma
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-PGLYRP2 antibody
Peptidoglycan recognition proteins (PGRPs) are pattern recognition molecules that recognize bacteria and their unique cell wall component, peptidoglycan (PGN). Mammals have four PGRPs, designated in humans PGRP-S (24kD), PGRPL (60-65kD), PGRP-I alpha (38kD), and PGRPI beta (44kD). Human PGRPs are differentially expressed in various tissues and organs: PGRP-S mainly in the bone marrow and Polymorphonuclear leukocyte (PMNs), PGRP-L mainly in the liver, and PGRP-Ia and PGRP-Ib mainly in the esophagus. The function of only one mammalian PGRP, PGRP-S, is currently known. Mouse PGRP-S is present in neutrophils and inhibits growth of Gram-positive bacteria and, therefore,may function as a neutrophil antibacterial protein.
Product Categories/Family for anti-PGLYRP2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
62,217 Da
NCBI Official Full Name
Peptidoglycan recognition protein 2
NCBI Official Synonym Full Names
peptidoglycan recognition protein 2
NCBI Official Symbol
PGLYRP2
NCBI Official Synonym Symbols
tagL; PGRPL; PGRP-L; PGLYRPL; HMFT0141; TAGL-like; tagl-beta; tagL-alpha
NCBI Protein Information
N-acetylmuramoyl-L-alanine amidase; peptidoglycan recognition protein L; peptidoglycan recognition protein long
UniProt Protein Name
N-acetylmuramoyl-L-alanine amidase
UniProt Gene Name
PGLYRP2
UniProt Synonym Gene Names
PGLYRPL; PGRPL; PGRP-L
UniProt Entry Name
PGRP2_HUMAN

NCBI Description

This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]

Uniprot Description

PGLYRP2: May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; EC 3.5.1.28; Secreted, signal peptide; Secreted; Receptor, misc.

Chromosomal Location of Human Ortholog: 19p13.12

Cellular Component: membrane; intracellular

Molecular Function: peptidoglycan receptor activity; peptidoglycan binding; zinc ion binding; N-acetylmuramoyl-L-alanine amidase activity

Biological Process: defense response to Gram-positive bacterium; negative regulation of natural killer cell differentiation during immune response; peptide amidation; detection of bacterium; negative regulation of interferon-gamma production; regulation of inflammatory response; innate immune response; pattern recognition receptor signaling pathway; peptidoglycan catabolic process

Research Articles on PGLYRP2

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Product Notes

The PGLYRP2 pglyrp2 (Catalog #AAA609787) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The PGRP-L (N-acetylmuramoyl-L-alanine Amidase, Peptidoglycan Recognition Protein 2, Peptidoglycan Recognition Protein Long, PGLYRP2, PGLYRPL, PGRPL, UNQ3103/PRO10102) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PGRP-L can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: Western Blot: 1:2,000. Researchers should empirically determine the suitability of the PGLYRP2 pglyrp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PGRP-L, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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