Mouse anti-Rat Nerve Growth Factor Receptor, p75NTR- FITC Monoclonal Antibody | anti-ngfr antibody
Nerve Growth Factor Receptor, p75NTR - FITC (Low-affinity NGF receptor, Gp80-LNGFR, p75 ICD, Low affinity neurotrophin receptor p75NTR)
Gene Names
ngfr; nrh1; CD271; NRH1b; p75ntr; p75(NTR); tnfrsf16; MGC131034; Gp80-LNGFR
Reactivity
Rat
Applications
Immunohistochemistry, Flow Cytometry, Functional Assay, Immunofluorescence
Purity
Affinity PurifiedPurified by affinity chromatography.
Synonyms
Nerve Growth Factor Receptor; p75NTR- FITC; Monoclonal Antibody; p75NTR - FITC (Low-affinity NGF receptor; Gp80-LNGFR; p75 ICD; Low affinity neurotrophin receptor p75NTR); Anti -Nerve Growth Factor Receptor; anti-ngfr antibody
Host
Mouse
Reactivity
Rat
Clonality
Monoclonal
Isotype
IgG2A
Clone Number
9G397
Specificity
Recognizes the extracellular domain of the neurotrophin receptor p75NTR in rat. May be used for immunocytochemical localisation of rat cells expressing p75NTR, ELISA and western blot. This antibody has also been used for the construction of the MC192-saporin immunotoxin for specific elimination of neuronal populations in basal forebrain cholinergic neurons to generate an animal model for Alzheimer's disease. Does not react with mouse
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Purified by affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with fluorescein isothiocyanate (FITC).
Applicable Applications for anti-ngfr antibody
Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes
Suitable for use in Immunofluorescence, Flow Cytometry, ELISA, Immunohistochemistry and Immunocytochemistry.
Dilution: Immunofluorescence: 1:10-1:50
Flow Cytometry: 20ug/ml
ELISA: 1:5000
Immunohistochemistry:1-2ug/ml
Immunocytochemistry: 1:10-1:50
Dilution: Immunofluorescence: 1:10-1:50
Flow Cytometry: 20ug/ml
ELISA: 1:5000
Immunohistochemistry:1-2ug/ml
Immunocytochemistry: 1:10-1:50
Immunogen
Synthetic peptide corresponding to Rat p75NTR.
Preparation and Storage
For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Related Product Information for anti-ngfr antibody
Nerve Growth Factor Receptor, p75NTR, generated by Chandlers et al. p75NTR, was originally discovered as a low affinity nerve growth factor receptor. Later it was found that it was the receptor for all neurotrophins. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. MC192 has a potential use as the ligand for gene delivery into p75NTR-expressing rat cells via a receptor-mediated mechanism. FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Subunit: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9.
Product Categories/Family for anti-ngfr antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
nerve growth factor receptor
NCBI Official Synonym Full Names
nerve growth factor receptor
NCBI Official Symbol
ngfr
NCBI Official Synonym Symbols
nrh1; CD271; NRH1b; p75ntr; p75(NTR); tnfrsf16; MGC131034; Gp80-LNGFR
NCBI Protein Information
nerve growth factor receptor; NRH; nerve growth factor receptor (TNFR superfamily, member 16)
Protein Family
Research Articles on ngfr
Similar Products
Product Notes
The ngfr (Catalog #AAA605114) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Nerve Growth Factor Receptor, p75NTR - FITC (Low-affinity NGF receptor, Gp80-LNGFR, p75 ICD, Low affinity neurotrophin receptor p75NTR) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Nerve Growth Factor Receptor, p75NTR- FITC can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF). Suitable for use in Immunofluorescence, Flow Cytometry, ELISA, Immunohistochemistry and Immunocytochemistry. Dilution: Immunofluorescence: 1:10-1:50 Flow Cytometry: 20ug/ml ELISA: 1:5000 Immunohistochemistry:1-2ug/ml Immunocytochemistry: 1:10-1:50. Researchers should empirically determine the suitability of the ngfr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Nerve Growth Factor Receptor, p75NTR- FITC, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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