Tenapanor, Inhibitor

Tenapanor

Cat. Num. AAA384292

• Purity: >98%
• Synonyms: Tenapanor; AZD1722; RDX5791; inhibitor

• Purity/Purification: >98%
• Form/Format: Powder
• Concentration: 0.1 mM: 8.73 mL (1 mg); 43.67 mL (5 mg); 87.33mL (10 mg); 0.5 mM: 1.75 mL (1 mg); 8.73 mL (5 mg); 17.47 mL (10 mg); 1 mM: 0.87 mL (1 mg); 4.37 mL (5 mg); 8.73 mL (10 mg); 5 mM: 0.17 mL (1 mg); 0.87 mL (5 mg); 1.75 mL (10 mg) (varies by lot)

• CAS Number: 1234423-95-0
• Formula: C50H66Cl4N8O10S2
• SMILES: CN1C[C@H](C2=CC(=CC(=C2C1)Cl)Cl)C3=CC(=CC=C3)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)C4=CC=CC(=C4)[C@@H]5CN(CC6=C(C=C(C=C56)Cl)Cl)C
• Actions: Inhibitor
• Availability: We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
• Preparation and Storage: at -20 degree C 3 years Powder

Chemical Structure

Related Product Information for Tenapanor, inhibitor

Tenapanor acts as an inhibitor of the sodium-proton exchanger NHE3. This antiporter protein is found in the kidney and intestines, and normally acts to regulate the levels of sodium absorbed and secreted by the body.

References

Yu Y, .et al. Expression, Localization and Functional Activity of the Major Na+/H+ Exchange Isoforms Expressed in the Intestinal Cell Line Caco-2BBe, Cell Physiol Biochem, 2019, 52(5):1017-1038 PMID: 30977986
Thammayon N, .et al. Na+/H+ exchanger 3 inhibitor diminishes the amino-acid-enhanced transepithelial calcium transport across the rat duodenum, Amino Acids, 2017, Apr;49(4):725-734 PMID: 27981415
Charoenphandhu N, .et al. Na+/H+ exchanger 3 inhibitor diminishes hepcidin-enhanced duodenal calcium transport in hemizygous β-globin knockout thalassemic mice, Mol Cell Biochem, 2017, Mar;427(1-2):201-208 PMID: 27995414
Jantarajit W, .et al. CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels, Am J Physiol Cell Physiol, 2017, Jul 1;313(1):C118-C129 PMID: 28490422