Western Blot (WB)
(Western blot detection of MAD3 in Hela,A549,HL-60 using MAD3 Rabbit mAb(1:1000 diluted))
Rabbit MAD3 Monoclonal Antibody | anti-MAD3 antibody
MAD3 Rabbit mAb
IHC: 1:50
FC: 1:20
Western Blot (WB)
(Western blot detection of MAD3 in Hela,A549,HL-60 using MAD3 Rabbit mAb(1:1000 diluted))
Western Blot (WB)
(Western blot detection of MAD3 in Hela,A549,HL-60 using MAD3 Rabbit mAb(1:1000 diluted))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
Uniprot Description
MXD3: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: nucleus
Molecular Function: protein dimerization activity; DNA binding
Biological Process: transcription, DNA-dependent; negative regulation of transcription, DNA-dependent
Research Articles on MAD3
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Product Notes
The MAD3 mxd3 (Catalog #AAA4753337) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MAD3 Rabbit mAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's MAD3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). WB: 1:1000 IHC: 1:50 FC: 1:20. Researchers should empirically determine the suitability of the MAD3 mxd3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MAD3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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