Mouse anti-Human LRRC4C Monoclonal Antibody | anti-LRRC4C antibody

LRRC4C (KIAA1580, NGL1, Leucine-rich Repeat-containing Protein 4C, Netrin-G1 Ligand))

Cat. Num. AAA649720

• Gene Names: LRRC4C; NGL1; NGL-1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: LRRC4C; Monoclonal Antibody; LRRC4C (KIAA1580; NGL1; Leucine-rich Repeat-containing Protein 4C; Netrin-G1 Ligand)); Anti -LRRC4C (KIAA1580; anti-LRRC4C antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a,k
• Clone Number: 1G5
• Specificity: Recognizes human LRRC4C.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.

• Applicable Applications for anti-LRRC4C antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.
• Immunogen: Partial recombinant corresponding to aa541-641 from human LRRC4C (NP_065980) with GST tag. MW of the GST tag alone is 26kD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot detection against Immunogen (37.11kD).)

Western Blot (WB)

(Western Blot analysis of LRRC4C expression in transfected 293T cell line by LRRC4C monoclonal antibody.|Lane 1: LRRC4C transfected lysate (71.9kD).|Lane 2: Non-transfected lysate.)

Testing Data

(Detection limit for recombinant GST tagged LRRC4C is 0.1ng/ml as a capture antibody.)

Related Product Information for anti-LRRC4C antibody

NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM].

Product Categories/Family for anti-LRRC4C antibody

Antibodies; Abs to Netrin

NCBI and Uniprot Product Information

• NCBI GI #: 73909151
• NCBI GeneID: 57689
• UniProt Accession #: Q9HCJ2; Q7L0N3; A8K0T1
• Molecular Weight: 71,950 Da
• NCBI Official Full Name: LRRC4C protein
• NCBI Official Synonym Full Names: leucine rich repeat containing 4C
• NCBI Official Symbol: LRRC4C
• NCBI Official Synonym Symbols: NGL1; NGL-1
• NCBI Protein Information: leucine-rich repeat-containing protein 4C; netrin-G1 ligand
• UniProt Protein Name: Leucine-rich repeat-containing protein 4C
• Protein Family: Leucine-rich repeat-containing protein
• UniProt Gene Name: LRRC4C
• UniProt Synonym Gene Names: KIAA1580; NGL1; NGL-1
• UniProt Entry Name: LRC4C_HUMAN

NCBI Description

NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM, Mar 2008]

Uniprot Description

Function: May promote neurite outgrowth of developing thalamic neurons. Ref.6

Subunit structure: Interacts with NTNG1 and WHRN. Ref.6

Subcellular location: Cell junction › synapse › postsynaptic cell membrane; Single-pass type I membrane protein Ref.6 Ref.7.

Tissue specificity: Highly expressed in the cerebral cortex, including frontal, parietal and occipital lobes. Putamen, amygdala, hippocampus and medulla oblongata show moderate expression. Caudate nucleus and thalamus express small amounts, whereas other brain regions show very weak or no expression. Ref.6

Domain: The LRR region is both necessary and sufficient for the interaction with NTNG1.

Sequence similarities: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 9 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 LRRNT domain.