Immunohistochemistry (IHC)
(Immunochemical staining of mouse LRPAP1 in mouse kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). The image showing staining of nephric tubule.)
Rabbit anti-Mouse LRPAP1 Monoclonal Antibody | anti-LRPAP1 antibody
Recombinant Anti-LRPAP1 Antibody, Rabbit Monoclonal
Gene Names
Lrpap1; RAP; HBP44; C77774; AA617339; AI790446; AU042172
Reactivity
Mouse
Applications
Immunohistochemistry
Purity
Protein A
Synonyms
LRPAP1; Monoclonal Antibody; Recombinant Anti-LRPAP1 Antibody; Rabbit Monoclonal; LRPAP1 Antibody; Rabbit MAb; low density lipoprotein receptor-related protein associated protein 1; Anti-AA617339 Antibody; Anti-AI790446 Antibody; Anti-AU042172 Antibody; Anti-C77774 Antibody; Anti-HBP44 Antibody; Anti-RAP Antibody; anti-LRPAP1 antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
011
Specificity
Mouse LRPAP1.
Has cross-reactivity in ELISA with Human LRPAP1
Has cross-reactivity in ELISA with Human LRPAP1
Has cross-reactivity in ELISA with Human LRPAP1
Has cross-reactivity in ELISA with Human LRPAP1
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-LRPAP1 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:100-1:500
Antibody Type
Recombinant Antibody
Immunogen
Recombinant Mouse LRPAP1 protein
Conjugation
Unconjugated
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse LRPAP1 (rM LRPAP1).
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of mouse LRPAP1 in mouse kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). The image showing staining of nephric tubule.)
Immunohistochemistry (IHC)
(Immunochemical staining of mouse LRPAP1 in mouse kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). The image showing staining of nephric tubule.)
Immunohistochemistry (IHC)
(Immunochemical staining of mouse LRPAP1 in mouse brain with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). The image showing staining of nerve cells.)
Immunohistochemistry (IHC)
(Immunochemical staining of mouse LRPAP1 in mouse brain with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). The image showing staining of nerve cells.)
Related Product Information for anti-LRPAP1 antibody
Receptor-associated protein (RAP) is a molecular chaperone for low-density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as alpha2-macroglobulin (alpha2 M) and apolipoprotein E. LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. The LRP-associated protein (LRPAP in humans, RAP in mice) acts as a chaperone protein, stabilizing the nascent LRP peptide in the endoplasmic reticulum and Golgi complex. Alpha-2-macroglobulin receptor-associated protein, also known as low-density lipoprotein receptor-related protein-associated protein 1, RAP, and LRPAP1, is a 39 kDa protein and a member of the alpha-2-MRAP family. It is a receptor antagonist that interacts with several members of the low-density lipoprotein (LDL) receptor gene family. Upon binding to these receptors, LRPAP1 inhibits all ligand interactions with the receptors. LRPAP1 is present on the cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. It binds with LRP1B and the binding is followed by internalization and degradation. LRPAP1 interacts with LRP1/alpha-2-macroglobulin receptor and LRP2 (previously called glycoprotein 330) and may be involved in the pathogenesis of membrane glomerular nephritis. LRPAP1 together with LRP2 forms the Heymann nephritis antigenic complex. LRP2 is expressed in epithelial cells of the thyroid, where it can serve as a receptor for the protein thyroglobulin. Intron 5 insertion/deletion polymorphism of RAP gene (LRPAP1) has been implicated in other diseases sharing etiology with gallstone disease (GSD). The LRPAP1 insertion/deletion polymorphism influences cholesterol homeostasis and may confer risk for gallstone disease and gallbladder carcinoma (GBC) incidence usually parallels with the prevalence of cholelithiasis. The genetic variations at the LRPAP1 locus may modulate Alzheimer's disease (AD) phenotype beyond risk for disease. Also, the variation in the LRPAP1 gene could contribute to the risk of developing an early episode of myocardial infarction (MI).
References
Gonzlez P, et al. (2002) Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction. Coron Artery Dis. 13(5): 251-4.Schutte DL, et al. (2003) A LRPAP1 intronic insertion/deletion polymorphism and phenotypic variability in Alzheimer disease. Res Theory Nurs Pract. 17(4): 301-19?Pandey SN, et al. (2006) Lipoprotein receptor associated protein (LRPAP1) insertion/deletion polymorphism: association with gallbladder cancer susceptibility. Int J Gastrointest Cancer. 37(4): 124-8.Dixit M, et al. (2006) Association of low density lipoprotein receptor related protein-associated protein (LRPAP1) gene insertion/deletion polymorphism with gallstone disease.J Gastroenterol Hepatol. 21(5): 847-9.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
42,215 Da
NCBI Official Full Name
alpha-2-macroglobulin receptor-associated protein
NCBI Official Synonym Full Names
low density lipoprotein receptor-related protein associated protein 1
NCBI Official Symbol
Lrpap1
NCBI Official Synonym Symbols
RAP; HBP44; C77774; AA617339; AI790446; AU042172
NCBI Protein Information
alpha-2-macroglobulin receptor-associated protein
UniProt Protein Name
Alpha-2-macroglobulin receptor-associated protein
Protein Family
UniProt Gene Name
Lrpap1
UniProt Synonym Gene Names
Alpha-2-MRAP; HBP-44; RAP
UniProt Entry Name
AMRP_MOUSE
Uniprot Description
LRPAP1: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis. Belongs to the alpha-2-MRAP family.
Protein type: Receptor, misc.
Cellular Component: cytoplasm; endoplasmic reticulum; plasma membrane; rough endoplasmic reticulum; vesicle
Molecular Function: low-density lipoprotein receptor binding; receptor antagonist activity
Biological Process: negative regulation of protein binding
Similar Products
Product Notes
The LRPAP1 lrpap1 (Catalog #AAA8111319) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Anti-LRPAP1 Antibody, Rabbit Monoclonal reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's LRPAP1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:100-1:500. Researchers should empirically determine the suitability of the LRPAP1 lrpap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LRPAP1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
