Rabbit anti-Human Latexin  Monoclonal Antibody | anti-LXN antibody

Rabbit anti Human Latexin  Monoclonal Antibody

Cat. Num. AAA2543883

• Gene Names: LXN; ECI; TCI
• Reactivity: Human
• Applications: Western Blot, ELISA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Flow Cytometry, Functional Assay
• Synonyms: Latexin ; Monoclonal Antibody; Rabbit anti Human Latexin Monoclonal Antibody; anti-LXN antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 222

• Applicable Applications for anti-LXN antibody: Western Blot (WB), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
• Application Notes: WB: 0.5-10 mug/mL; ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human LXN. The detection limit for Human LXN is approximately 0.00245 ng/well.; Flow Cytometry: 0.5-2 mug/Test; ICC/IF: 10-25 mug/mL; IP: 4-6 mug/mg of lysate
• Immunogen: Recombinant Human Latexin/LXN Protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-LXN antibody

Mouse Latexin, also known as endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor, TCI, ECI and LXN, is a cytoplasm protein which belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in heart, prostate, ovary, kidney, pancreas, and colon. Latexin/LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart, prostate, ovary, kidney, pancreas, and colon, but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets, and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors, Latexin is related to a human putative tumor suppressor protein, TIG1. In addition, Latexin is also implicated in Alzheimer's disease.

NCBI and Uniprot Product Information

• NCBI GI #: 194473714
• NCBI GeneID: 56925
• NCBI GenBank Nucleotide #: NM_020169.3
• Molecular Weight: 25,750 Da
• NCBI Official Full Name: latexin
• NCBI Official Synonym Full Names: latexin
• NCBI Official Symbol: LXN
• NCBI Official Synonym Symbols: ECI; TCI
• NCBI Protein Information: latexin
• UniProt Protein Name: Latexin
• Protein Family: Latexin
• UniProt Gene Name: LXN
• UniProt Synonym Gene Names: ECI; TCI
• UniProt Entry Name: LXN_HUMAN

NCBI Description

This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008]

Uniprot Description

LXN: Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. Belongs to the protease inhibitor I47 (latexin) family.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 3q25.32

Molecular Function: protein binding