Mouse Lamin A/C Monoclonal Antibody
Lamin A/C antibody
Applications
Flow Cytometry, Functional Assay, Immunohistochemistry, Immunohistochemistry, Western Blot
Synonyms
Lamin A/C; Monoclonal Antibody; Lamin A/C antibody; Monoclonal Lamin A/C; Anti-Lamin A/C; Lamin A; Lamin C; anti-Lamin A/C antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
131C3
Specificity
Reacts with an epitope located between residues 319-566 in lamin A and C
Form/Format
Supplied in PBS containing 0.09% sodium azide
Applicable Applications for anti-Lamin A/C antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunohistochemistry (IHC) Formalin, Western Blot (WB)
Application Notes
FC: 1:100-1:200
IHC: 1:100-1:200
WB: 1:100-1:1000
IHC: 1:100-1:200
WB: 1:100-1:1000
Biological Significance
Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A, B and C. The lamin A/C (LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and lamin C. Lamin A/C mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy and Hutchinson-Gilford progeria syndrome. Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.
Cross-Reactivity
Bovine, Canine, Hamster, Human, Mouse, Rat, Sheep
Immunogen
Lamin A/C antibody was raised in Mouse using purified rat liver lamins as the immunogen.
Related Product Information for anti-Lamin A/C antibody
Mouse monoclonal Lamin A/C antibody
Product Categories/Family for anti-Lamin A/C antibody
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Product Notes
The Lamin A/C (Catalog #AAA834537) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Lamin A/C can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunohistochemistry (IHC) Formalin, Western Blot (WB). FC: 1:100-1:200 IHC: 1:100-1:200 WB: 1:100-1:1000. Researchers should empirically determine the suitability of the Lamin A/C for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Lamin A/C, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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