Mouse Kv3.1b K+ Channel Monoclonal Antibody | anti-Kcnc1 antibody
Anti-Kv3.1b K+ Channel Monoclonal Antibody
Gene Names
Kcnc1; Kv4; Kv3.1; KShIIIB; NGK2-KV4
Reactivity
Human, mouse, rat
Applications
Immunoblot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Synonyms
Kv3.1b K+ Channel; Monoclonal Antibody; Anti-Kv3.1b K+ Channel Monoclonal Antibody; anti-Kcnc1 antibody
Host
Mouse
Reactivity
Human, mouse, rat
Clonality
Monoclonal
Isotype
lgG1
Clone Number
S16B-8
Specificity
Kv3.1b K+ Channel
This antibody recognizes human (weak), mouse, and rat Kv3.1b.
This antibody recognizes human (weak), mouse, and rat Kv3.1b.
Form/Format
100ug in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.
Sequence Positions
437-585
Applicable Applications for anti-Kcnc1 antibody
Immunoblot; Immunohistochemistry; Immunocytochemistry; Immunofluorescence
Application Notes
Immunoblotting: use at 1-10ug/ml. A band of -110kDa is detected. Immunohistochemistry and Immunocytochemistry. use at 0.1-1ug/ml. Immunofluorescence: use at 1-10ug/ml. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain lysate
Antigen
Fusion protein aa 437-585 (cytoplasmic C-terminus) of rat Kv3.1b (accession number NP_036988)
Dilution Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.
Related Product Information for anti-Kcnc1 antibody
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. The protein encoded by the Kv3.1b gene is a member of the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Diminshed Kv3.1b expression appears to correlate with functional decline in the medial olivocochlear efferent system. Other studies indicate that Kv3.1b channels can be oxygen sensors.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
65,857 Da
NCBI Official Full Name
potassium voltage-gated channel subfamily C member 1
NCBI Official Synonym Full Names
potassium voltage gated channel, Shaw-related subfamily, member 1
NCBI Official Symbol
Kcnc1
NCBI Official Synonym Symbols
Kv4; Kv3.1; KShIIIB; NGK2-KV4
NCBI Protein Information
potassium voltage-gated channel subfamily C member 1; NGK2; RAW2; potassium channel gene 1; voltage-gated potassium channel subunit Kv4; voltage-gated potassium channel subunit Kv3.1
UniProt Protein Name
Potassium voltage-gated channel subfamily C member 1
Protein Family
UniProt Gene Name
Kcnc1
UniProt Entry Name
KCNC1_RAT
NCBI Description
voltage gated potassium channel; functions as a delayed rectifier K+ channel [RGD]
Uniprot Description
Kv3.1: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily.
Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: voltage-gated potassium channel complex; cell surface; membrane; cell soma; dendrite; integral to membrane; axolemma
Molecular Function: voltage-gated potassium channel activity; protein binding; kinesin binding; delayed rectifier potassium channel activity
Biological Process: response to toxin; response to light intensity; cerebellum development; globus pallidus development; brain development; protein homooligomerization; response to amine stimulus
Research Articles on Kcnc1
Similar Products
Product Notes
The Kcnc1 kcnc1 (Catalog #AAA190529) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 437-585. The Anti-Kv3.1b K+ Channel Monoclonal Antibody reacts with Human, mouse, rat and may cross-react with other species as described in the data sheet. AAA Biotech's Kv3.1b K+ Channel can be used in a range of immunoassay formats including, but not limited to, Immunoblot; Immunohistochemistry; Immunocytochemistry; Immunofluorescence. Immunoblotting: use at 1-10ug/ml. A band of -110kDa is detected. Immunohistochemistry and Immunocytochemistry. use at 0.1-1ug/ml. Immunofluorescence: use at 1-10ug/ml. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain lysate. Researchers should empirically determine the suitability of the Kcnc1 kcnc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Kv3.1b K+ Channel, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
