Mouse anti-Mouse, Rat AcCoA Carboxylase Monoclonal Antibody | anti-Acaca antibody

AcCoA Carboxylase (Ser79), phosphorylated (MaxLight 490)

Cat. Num. AAA6245579

• Gene Names: Acaca; ACC1; Acac
• Reactivity: Mouse, Rat
• Applications: Western Blot
• Purity: Purified by Protein G Affinity Chromatography
• Synonyms: AcCoA Carboxylase; Monoclonal Antibody; AcCoA Carboxylase (Ser79); phosphorylated (MaxLight 490); anti-Acaca antibody

• Host: Mouse
• Reactivity: Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG1, lambda
• Clone Number: 3J1
• Specificity: Recognizes phosphorylated rat Acetyl CoA Carboxylase (Ser79), Mr 257kD. Species Crossreactivity: mouse.
• Purity/Purification: Purified by Protein G Affinity Chromatography
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

• Applicable Applications for anti-Acaca antibody: Western Blot (WB)
• Immunogen: Synthetic peptide containing (...SSM[pS]GL), in which [pS] corresponds to phospho-Serine at residue 79 of rat AcCoA Carboxylase conjugated to KLH.
• Conjugate: MaxLight490
• Preparation and Storage: Store at 4 degree C. Do Not Freeze.

Testing Data

(Mouse heart cytosolic lysate was probed withMBS601600.)

Product Categories/Family for anti-Acaca antibody

Antibodies; Enzymes

References

1. Chen, Z.P., et al., Am. J. Physiol. Endocrinol. Metab. 279: E1202-E1206 (2000). 2. Kemp, B.E., et al., Trends Biochem. Sci. 24: 22-25 (1999)

NCBI and Uniprot Product Information

• NCBI GI #: 11559962
• NCBI GeneID: 60581
• NCBI Accession #: NP_071529.1
• NCBI GenBank Nucleotide #: NM_022193.1
• UniProt Accession #: P11497; P97902; A1EC79
• Molecular Weight: 264,328 Da
• NCBI Official Full Name: acetyl-CoA carboxylase 1
• NCBI Official Synonym Full Names: acetyl-CoA carboxylase alpha
• NCBI Official Symbol: Acaca
• NCBI Official Synonym Symbols: ACC1; Acac
• NCBI Protein Information: acetyl-CoA carboxylase 1
• UniProt Protein Name: Acetyl-CoA carboxylase 1
• UniProt Gene Name: Acaca
• UniProt Synonym Gene Names: Acac; ACC1

NCBI Description

catalyzes the rate-limiting carboxylation of acetyl CoA to malonyl CoA during long-chain fatty acid synthesis [RGD, Feb 2006]

Uniprot Description

ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity.

Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: actin cytoskeleton; cytosol; extracellular exosome; fibrillar center; mitochondrion

Molecular Function: acetyl-CoA carboxylase activity; ATP binding; biotin binding; biotin carboxylase activity; identical protein binding; kinase binding; metal ion binding

Biological Process: acetyl-CoA metabolic process; cellular response to prostaglandin E stimulus; fatty acid biosynthetic process; lipid homeostasis; lipid metabolic process; malonyl-CoA biosynthetic process; multicellular organismal protein metabolic process; protein homotetramerization; response to drug; response to organic cyclic compound; tissue homeostasis