Immunohistochemistry (IHC)
(Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE))
Mouse anti-Porcine Keratin 8, 18,19 Monoclonal Antibody | anti-KRT19 antibody
Keratin 8, 18,19 (Keratin Type II Cytoskeletal 8, Keratin 8, Keratin-8, K8, KRT8, Keratin Type I Cytoskeletal 18, Keratin 18, Keratin-18, K18, KRT18, CARD2, Cell Proliferation-inducing Gene 46 Protein, Cytokeratin-8, CK8, CK-8, CYK8, Cytokeratin-18, CK-18
Purified by Fast protein liquid chromatography.
Purified by Fast protein liquid chromatography.
Dilution: Western Blot: 1:1000-1:4000
Immunohistochemistry (Formalin fixed paraffin embedded): 1:100
Immunohistochemistry (Frozen): 1:200
Immunohistochemistry (IHC)
(Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry (IHC)
(Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Ref.14
Subunit structure: Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein. Ref.13 Ref.14
Tissue specificity: Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin. Ref.2 Ref.4 Ref.14
Developmental stage: Present in hair follicles at all stages of development. Ref.4
Domain: This keratin differs from all other IF proteins in lacking the C-terminal tail domain.
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Sequence similarities: Belongs to the intermediate filament family.
Research Articles on KRT19
Similar Products
Product Notes
The KRT19 krt19 (Catalog #AAA645955) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Keratin 8, 18,19 (Keratin Type II Cytoskeletal 8, Keratin 8, Keratin-8, K8, KRT8, Keratin Type I Cytoskeletal 18, Keratin 18, Keratin-18, K18, KRT18, CARD2, Cell Proliferation-inducing Gene 46 Protein, Cytokeratin-8, CK8, CK-8, CYK8, Cytokeratin-18, CK-18 reacts with Porcine and may cross-react with other species as described in the data sheet. AAA Biotech's Keratin 8, 18,19 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot and Immunohistochemistry. Dilution: Western Blot: 1:1000-1:4000 Immunohistochemistry (Formalin fixed paraffin embedded): 1:100 Immunohistochemistry (Frozen): 1:200. Researchers should empirically determine the suitability of the KRT19 krt19 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Keratin 8, 18,19, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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