Mouse anti-Human KCNQ1 Monoclonal Antibody | anti-Kcnq1 antibody

KCNQ1

Cat. Num. AAA6007938

• Gene Names: Kcnq1; Kcna9; KVLQT1; AW559127
• Reactivity: Human
• Applications: ELISA, Western Blot, Flow Cytometry, Functional Assay
• Purity: Ascites
• Synonyms: KCNQ1; Monoclonal Antibody; Anti -KCNQ1; anti-Kcnq1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 13B436
• Specificity: Human
• Purity/Purification: Ascites
• Form/Format: Ascites fluid, 0.03% sodium azide.

• Applicable Applications for anti-Kcnq1 antibody: ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
• Application Notes: Western Bloting: 1:500-1:2000., Flow cytometry: 1:200-1:400., ELISA: Suggested dilution 1:10000., Optimal dilutions to be determined by the researcher.
• Immunogen: Purified recombinant fragment of human KCNQ1 expressed in E. coli.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-Kcnq1 antibody

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. 

Product Categories/Family for anti-Kcnq1 antibody

Antibodies; Abs to Cardiac Markers

NCBI and Uniprot Product Information

• NCBI GI #: 3319981
• NCBI GeneID: 16535
• UniProt Accession #: P97414; O88702; Q3U4H1; Q7TNZ1; Q7TPL7; Q80VR7
• Molecular Weight: 74,514 Da
• NCBI Official Full Name: Kcnq1
• NCBI Official Synonym Full Names: potassium voltage-gated channel, subfamily Q, member 1
• NCBI Official Symbol: Kcnq1
• NCBI Official Synonym Symbols: Kcna9; KVLQT1; AW559127
• NCBI Protein Information: potassium voltage-gated channel subfamily KQT member 1; KQT-like 1; voltage-gated potassium channel subunit Kv7.1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
• UniProt Protein Name: Potassium voltage-gated channel subfamily KQT member 1
• Protein Family: KCNQ1 downstream neighbor protein
• UniProt Gene Name: Kcnq1
• UniProt Synonym Gene Names: Kcna9; Kvlqt1
• UniProt Entry Name: KCNQ1_MOUSE

Uniprot Description

Kv7.1: a voltage-gated potassium channel protein required for the repolarization phase of the cardiac action potential. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea. Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries. Three alternatively spliced isoforms have been described.

Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: voltage-gated potassium channel complex; zymogen granule membrane; cytoplasmic vesicle membrane; membrane; basolateral plasma membrane; integral to plasma membrane; lysosome; early endosome; late endosome; integral to membrane; plasma membrane; cytoplasmic vesicle; sarcolemma

Molecular Function: calmodulin binding; voltage-gated potassium channel activity; protein homodimerization activity; potassium channel activity; outward rectifier potassium channel activity; delayed rectifier potassium channel activity; ion channel activity; voltage-gated ion channel activity; protein phosphatase 1 binding

Biological Process: regulation of membrane potential; genetic imprinting; transport; positive regulation of heart rate; ion transport; gene silencing; transmembrane transport; potassium ion transport; cardiac muscle contraction; negative regulation of insulin secretion