Mouse anti-Human JAML Monoclonal Antibody | anti-JAML antibody
Anti-JAML Antibody (HRP), Mouse Monoclonal
Gene Names
AMICA1; JAML; AMICA; Gm638; CREA7-1; CREA7-4
Reactivity
Human
Applications
ELISA
Purity
Protein A
Synonyms
JAML; Monoclonal Antibody; Anti-JAML Antibody (HRP); Mouse Monoclonal; JAML/AMICA1 Antibody (HRP); Mouse MAb; adhesion molecule; interacts with CXADR antigen 1; Anti-AMICA Antibody; Anti-CREA7-1 Antibody; Anti-CREA7-4 Antibody; Anti-Gm638 Antibody; Anti-JAML Antibody; anti-JAML antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone Number
06
Specificity
Human JAML/AMICA1
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-JAML antibody
ELISA (EIA)
Application Notes
ELISA: 0.1-1ug/ml
Immunogen
Recombinant Human JAML/AMICA1 Protein
Conjugation
HRP
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human JAML/AMICA1 (rh JAML/AMICA1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP).
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Protected from prolonged exposure to light. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-JAML antibody
Junctional adhesion molecules (JAMs) are endothelial and epithelial adhesion molecules involved in the recruitment of circulating leukocytes to inflammatory sites. JAML (Junctional adhesion molecule-like), also known as AMICA1 (Adhesion molecule interacting with CXADR antigen 1), a protein related to the JAM family, is restricted to leukocytes and promotes their adhesion to endothelial cells. It contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail involved in activation signaling. Monocytic JAML/AMICA1 plays a critical role in regulating monocyte transendothelial migration (TEM) probably via binding to the endothelial coxsackie and adenovirus receptor (CAR) and other tight junction-associated adhesive molecules. The Expression of JAML/AMICA1 is restricted to the hematopoietic tissues with the exception of liver. JAML may function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, JAML/AMICA1 also enhances myeloid leukemia cell adhesion to endothelial cells.
References
Moog-Lutz C, et al. (2003) JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Blood. 102(9): 3371-8.Luissint AC, et al. (2008) JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation. J Cell Biol. 183(6): 1159-73.Guo YL, et al. (2009) Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration. Arterioscler Thromb Vasc Biol. 29(1): 75-83.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
40,136 Da
NCBI Official Full Name
junctional adhesion molecule-like isoform 1
NCBI Official Synonym Full Names
adhesion molecule, interacts with CXADR antigen 1
NCBI Official Symbol
AMICA1
NCBI Official Synonym Symbols
JAML; AMICA; Gm638; CREA7-1; CREA7-4
NCBI Protein Information
junctional adhesion molecule-like; adhesion molecule AMICA; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; adhesion molecule interacting with CXADR antigen 1
UniProt Protein Name
Junctional adhesion molecule-like
Protein Family
UniProt Gene Name
AMICA1
UniProt Synonym Gene Names
JAML; UNQ722/PRO1387
UniProt Entry Name
JAML1_HUMAN
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Product Notes
The JAML amica1 (Catalog #AAA8101078) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-JAML Antibody (HRP), Mouse Monoclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's JAML can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 0.1-1ug/ml. Researchers should empirically determine the suitability of the JAML amica1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "JAML, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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