Immunohistochemistry (IHC)
(Immunohistochemical staining of JAG1 using MBS6005237 in Pancreas, Acini and Duct (2.5ug/ml).|This antibody has been tested in immunohistochemistry, analyzed by an anatomic pathologist and validated for use in IHC applications against formalin-fixed, paraffin-embedded human tissues. The image shows the localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain.)
Mouse Jagged-1 Monoclonal Antibody
Jagged-1 (Protein Jagged-1, CD339, JAG1)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Immunohistochemistry (IHC)
(Immunohistochemical staining of JAG1 using MBS6005237 in Pancreas, Acini and Duct (2.5ug/ml).|This antibody has been tested in immunohistochemistry, analyzed by an anatomic pathologist and validated for use in IHC applications against formalin-fixed, paraffin-embedded human tissues. The image shows the localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain.)
Immunohistochemistry (IHC)
(Immunohistochemical staining of JAG1 using MBS6005237 in Pancreas, Acini and Duct (2.5ug/ml).|This antibody has been tested in immunohistochemistry, analyzed by an anatomic pathologist and validated for use in IHC applications against formalin-fixed, paraffin-embedded human tissues. The image shows the localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain.)
Western Blot (WB)
(Western blot analysis using MBS6005237 at 1:1'000 dilution.|1: Human Jagged-1 Fc fusion protein.|2. Transfected human Jagged-1 cell lysate.|3. Mock transfected HEK 293 cell lysate.)
Western Blot (WB)
(Western blot analysis using MBS6005237 at 1:1'000 dilution.|1: Human Jagged-1 Fc fusion protein.|2. Transfected human Jagged-1 cell lysate.|3. Mock transfected HEK 293 cell lysate.)
Testing Data
(SPR analysis of the interaction between anti-Jagged-1 (human), mAb derivative hJagged1-Fc fusion protein. SPR response was taken when 13, 6.5, 3.25, 1.625, and 0.8125nM of J1G53-3 were injected onto the hJagged1-Fc fusion protein. J1G53-3 exhibited the highest binding affinity, and its property and binding ability was studied in detail by spectroscopy and surface Plasmon resonance (SPR). The result acquired through SPR was as follows: Kd value was1.08nM and value of chi-square was 0.0237 through SPR analysis.)
Testing Data
(SPR analysis of the interaction between anti-Jagged-1 (human), mAb derivative hJagged1-Fc fusion protein. SPR response was taken when 13, 6.5, 3.25, 1.625, and 0.8125nM of J1G53-3 were injected onto the hJagged1-Fc fusion protein. J1G53-3 exhibited the highest binding affinity, and its property and binding ability was studied in detail by spectroscopy and surface Plasmon resonance (SPR). The result acquired through SPR was as follows: Kd value was1.08nM and value of chi-square was 0.0237 through SPR analysis.)
Testing Data
(SPR analysis of the interaction between anti-Jagged-1 (human), mAb derivative hJagged1-Fc fusion protein. SPR response was taken when 13, 6.5, 3.25, 1.625, and 0.8125nM of J1G53-3 were injected onto the hJagged1-Fc fusion protein. J1G53-3 exhibited the highest binding affinity, and its property and binding ability was studied in detail by spectroscopy and surface Plasmon resonance (SPR). The result acquired through SPR was as follows: Kd value was1.08nM and value of chi-square was 0.0237 through SPR analysis.)
Testing Data
(SPR analysis of the interaction between anti-Jagged-1 (human), mAb derivative hJagged1-Fc fusion protein. SPR response was taken when 13, 6.5, 3.25, 1.625, and 0.8125nM of J1G53-3 were injected onto the hJagged1-Fc fusion protein. J1G53-3 exhibited the highest binding affinity, and its property and binding ability was studied in detail by spectroscopy and surface Plasmon resonance (SPR). The result acquired through SPR was as follows: Kd value was1.08nM and value of chi-square was 0.0237 through SPR analysis.)
NCBI and Uniprot Product Information
NCBI Description
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
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Product Notes
The Jagged-1 (Catalog #AAA6005237) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Jagged-1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). Suitable for use in ELISA, Flow Cytometry, Immunohistochemistry, Western Blot. Researchers should empirically determine the suitability of the Jagged-1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Jagged-1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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