Mouse Integrin alpha 3A Monoclonal Antibody | anti-Itga3 antibody
Mouse monoclonal Integrin alpha 3A antibody
WB: 1:100-1:1000
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a subunit of integrin family of cell surface proteins. The encoded protein undergoes post-translational processing to form a disulfide bond-linked dimer comprised of heavy and light chains. At the cell surface, the encoded protein non-covalently associates with the integrin beta-1 subunit to form a heterodimer that interacts with many extracellular matrix proteins including fibronectin and laminin. Mice lacking the encoded protein die during the first day after birth due to severe abnormalities in kidneys. Mice lacking the encoded protein specifically in the basal layer of epidermis display several skin defects and accelerated wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Uniprot Description
ITGA3: an integral membrane protein that heterodimerizes with a beta chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. Undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1. Two alternatively spliced isoforms have been described.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 11 D|11 59.01 cM
Cellular Component: basolateral plasma membrane; cell surface; excitatory synapse; external side of plasma membrane; filopodium membrane; focal adhesion; growth cone; perinuclear region of cytoplasm; plasma membrane; receptor complex; synapse
Molecular Function: collagen binding; fibronectin binding; glycoprotein binding; integrin binding; laminin binding; protease binding; protein binding; protein domain specific binding; protein heterodimerization activity
Biological Process: cell adhesion; fusion of sperm to egg plasma membrane; lung development; memory; negative regulation of cell projection organization and biogenesis; negative regulation of Rho protein signal transduction; neuron migration; regulation of BMP signaling pathway; regulation of transforming growth factor beta receptor signaling pathway; regulation of Wnt receptor signaling pathway; skin development
Research Articles on Itga3
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Product Notes
The Itga3 itga3 (Catalog #AAA5306516) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Integrin alpha 3A can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Formalin, Western Blot (WB). IHC: 1:100-1:200 WB: 1:100-1:1000. Researchers should empirically determine the suitability of the Itga3 itga3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Integrin alpha 3A, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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