anti-Human Insulin Like Growth Factor Binding Protein I (IGFBP-I) Monoclonal Antibody | anti-IGFBP1 antibody

MAb to IGFBP-I

Cat. Num. AAA311361

• Gene Names: IGFBP1; AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: >=95% pure. Protein G chromatography
• Synonyms: Insulin Like Growth Factor Binding Protein I (IGFBP-I); Monoclonal Antibody; MAb to IGFBP-I; Monoclonal Antibody to Human Insulin Like Growth Factor Binding Protein I (IGFBP-I); anti-IGFBP1 antibody

• Host: Host: Mouse. Hybridization of Sp 2/0 myeloma cells with spleen cells from Balb/c mice.; Source: Ascites
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: G2
• Specificity: Insulin Like Growth Factor Binding Protein I (IGFBP-I); Human IGFBP-I
• Purity/Purification: >=95% pure. Protein G chromatography
• Form/Format: Purified, Liquid
• Concentration: 0.8mg/ml (OD280nm, E^0.1% = 1.4) (varies by lot)

• Applicable Applications for anti-IGFBP1 antibody: EIA/ELISA, Western Blot
• Immunogen: Purified IGFBP-I from human amniotic fluid
• Affinity Constant: Not determined
• Buffer: PBS, pH 7.4
• Preservative: 0.1% Sodium azide
• Important Note: Centrifuge before opening to ensure complete recovery of vial contents.
• Warnings: This product contains sodium azide, which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
• Preparation and Storage: Store at 2 to 8 degree C.

Product Categories/Family for anti-IGFBP1 antibody

Monoclonal Antibodies to Cytokines and Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 4504615
• NCBI GeneID: 3484
• NCBI Accession #: NP_000587.1
• NCBI GenBank Nucleotide #: NM_000596.2
• UniProt Accession #: P08833; Q8IYP5; A4D2F4; D3DVL9; Q6PEY6
• Molecular Weight: 27,904 Da
• NCBI Official Full Name: insulin-like growth factor-binding protein 1
• NCBI Official Synonym Full Names: insulin-like growth factor binding protein 1
• NCBI Official Symbol: IGFBP1
• NCBI Official Synonym Symbols: AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1
• NCBI Protein Information: insulin-like growth factor-binding protein 1; IBP-1; IGFBP-1; OTTHUMP00000159561; OTTHUMP00000207990; OTTHUMP00000214348; binding protein-25; binding protein-26; binding protein-28; placental protein 12; IGF-binding protein 1; amniotic fluid binding protein; growth hormone independent-binding protein; alpha-pregnancy-associated endometrial globulin
• UniProt Protein Name: Insulin-like growth factor-binding protein 1
• Protein Family: Insulin-like growth factor-binding protein
• UniProt Gene Name: IGFBP1
• UniProt Synonym Gene Names: IBP1
• UniProt Entry Name: IBP1_HUMAN

NCBI Description

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq]

Uniprot Description

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. Ref.19

Subunit structure: Binds equally well IGF1 and IGF2.

Subcellular location: Secreted.

Post-translational modification: Phosphorylated; probably by casein kinase II. Alters the affinity of the protein for IGFs. Ref.17 Ref.19

Sequence similarities: Contains 1 IGFBP N-terminal domain.Contains 1 thyroglobulin type-1 domain.

Sequence caution: The sequence AAA52540.1 differs from that shown. Reason: Frameshift at positions 55 and 71.