Mouse anti-Human IL33 Monoclonal Antibody | anti-IL33 antibody

IL33 Mouse Monoclonal

Cat. Num. AAA7600505

• Gene Names: IL33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Protein A+G purification
• Synonyms: IL33; Monoclonal Antibody; IL33 Mouse Monoclonal; anti-IL33 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Purity/Purification: >=95% as determined by SDS-PAGE; Protein A+G purification
• Form/Format: Liquid
• Sequence Length: 264

• Applicable Applications for anti-IL33 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Interleukin 33
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human nasopharyngeal carcinoma tissue slide using MBS7600505 (IL33 Antibody) at dilution of 1:200)

Western Blot (WB)

(HepG2 cells were subjected to SDS PAGE followed by western blot with MBS7600505 (IL33 Antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 930588935
• NCBI GeneID: 90865
• NCBI Accession #: NP_001300976.1
• NCBI GenBank Nucleotide #: NM_001314047.1
• Molecular Weight: 16,250 Da
• NCBI Official Full Name: interleukin-33 isoform d
• NCBI Official Synonym Full Names: interleukin 33
• NCBI Official Symbol: IL33
• NCBI Official Synonym Symbols: DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26
• NCBI Protein Information: interleukin-33
• UniProt Protein Name: Interleukin-33
• Protein Family: Interleukin
• UniProt Gene Name: IL33
• UniProt Synonym Gene Names: C9orf26; IL1F11; NFHEV; IL-33; IL-1F11; NF-HEV
• UniProt Entry Name: IL33_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Uniprot Description

IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: chromosome; extracellular region; extracellular space; nucleus; transport vesicle

Molecular Function: cytokine activity; protein binding

Biological Process: defense response to virus; negative regulation of immunoglobulin secretion; negative regulation of interferon-gamma production; negative regulation of leukocyte migration; negative regulation of T-helper 1 type immune response; positive regulation of immunoglobulin secretion; positive regulation of inflammatory response; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-5 production; positive regulation of interleukin-6 production; positive regulation of macrophage activation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of T-helper 2 type immune response; positive regulation of transcription from RNA polymerase II promoter; T-helper 2 type immune response; transcription, DNA-dependent