Rabbit anti-Human IL1R1  Monoclonal Antibody | anti-IL1R1  antibody

Rabbit anti Human IL1R1  Monoclonal Antibody

Cat. Num. AAA2543852

• Gene Names: IL1R1; P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha
• Reactivity: Human
• Applications: ELISA
• Synonyms: IL1R1 ; Monoclonal Antibody; Rabbit anti Human IL1R1 Monoclonal Antibody; anti-IL1R1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 166

• Applicable Applications for anti-IL1R1 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human IL-1R1/CD121a.
• Immunogen: Recombinant Human IL-1R1/CD121a Protein
• Buffer: PBS, 5% Trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-IL1R1  antibody

Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1beta activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1beta induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.

NCBI and Uniprot Product Information

• NCBI GI #: 1005261083
• NCBI GeneID: 3554
• NCBI GenBank Nucleotide #: NM_001320986.1
• Molecular Weight: 65,402 Da
• NCBI Official Full Name: interleukin-1 receptor type 1 isoform 6
• NCBI Official Synonym Full Names: interleukin 1 receptor type 1
• NCBI Official Symbol: IL1R1
• NCBI Official Synonym Symbols: P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha
• NCBI Protein Information: interleukin-1 receptor type 1
• UniProt Protein Name: Interleukin-1 receptor type 1
• UniProt Gene Name: IL1R1
• UniProt Synonym Gene Names: IL1R; IL1RA; IL1RT1; IL-1R-1; IL-1RT-1; IL-1RT1; IL-1R-alpha; mIL-1R1; mIL-1RI; sIL-1R1; sIL-1RI
• UniProt Entry Name: IL1R1_HUMAN

NCBI Description

This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]

Uniprot Description

IL-1RA: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Belongs to the interleukin-1 receptor family.

Protein type: EC 2.7.11.25; Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function: interleukin-1 receptor activity; platelet-derived growth factor receptor binding; protein binding; signal transducer activity; transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; immune response