Mouse anti-Human IL17RA/CD217 Monoclonal Antibody | anti-IL17RA/CD217 antibody

Mouse anti Human IL17RA/CD217 Monoclonal Antibody

Cat. Num. AAA2543503

• Gene Names: IL17RA; CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R
• Reactivity: Human
• Applications: ELISA
• Synonyms: IL17RA/CD217; Monoclonal Antibody; Mouse anti Human IL17RA/CD217 Monoclonal Antibody; anti-IL17RA/CD217 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Sequence Length: 832

• Applicable Applications for anti-IL17RA/CD217 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.5-1 mug/mL. This antibody can be used at 0.5-1 mug/mL with the appropriate secondary reagents to detect Human IL17RA. The detection limit for Human IL17RA is 0.0195 ng/well.
• Immunogen: Recombinant Human IL17RA protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 583966138
• NCBI GeneID: 23765
• NCBI GenBank Nucleotide #: NM_001289905.1
• Molecular Weight: 92,153 Da
• NCBI Official Full Name: interleukin-17 receptor A isoform 2
• NCBI Official Synonym Full Names: interleukin 17 receptor A
• NCBI Official Symbol: IL17RA
• NCBI Official Synonym Symbols: CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R
• NCBI Protein Information: interleukin-17 receptor A
• UniProt Protein Name: Interleukin-17 receptor A
• UniProt Gene Name: IL17RA
• UniProt Synonym Gene Names: IL17R; IL-17 receptor A; IL-17RA
• UniProt Entry Name: I17RA_HUMAN

NCBI Description

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

Uniprot Description

IL17RA: Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. Widely expressed.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 22q11.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: interleukin-17 receptor activity; protein binding

Biological Process: positive regulation of interleukin-23 production

Disease: Candidiasis, Familial, 5