Rat anti-Human IGF-1R Monoclonal Antibody | anti-IGF-1R antibody
IGF-1R, Human, mAb 1B1
Gene Names
IGF1R; IGF-1R
Reactivity
Human
Synonyms
IGF-1R; Monoclonal Antibody; Human; mAb 1B1; anti-IGF-1R antibody
Host
Rat
Reactivity
Human
Clonality
Monoclonal
Form/Format
1 ml (100 mug/ml) 0.2 mum protein G purified antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)
Sequence Length
1363
Application Notes
The typical starting working dilution is 1:50.
Preparation and Storage
Should be stored at 4 degree C.
Under recommended storage conditions, product is stable for one year.
Under recommended storage conditions, product is stable for one year.
Related Product Information for anti-IGF-1R antibody
Monoclonal antibody HM2340, clone 1B1 recognizes human insulin growth factor 1 receptor. IGF-1R is a heterotetrameric transmembrane tyrosine kinase receptor expressed by many cells like lymphoid and myeloid cells as well as non haematopoietic cells. The receptor consists of two extracellular alpha subunits and two beta subunits with tyrosine kinase activity. Receptor autophosphorylation follows by binding of its ligands insulin-like growth factor 1 and 2. The IGF/IGF-1R pathway plays important and diverse roles in tissue development and function, cell cycle progression, apoptosis and translation of proteins. IGF-1R regulates normal as well as pathological responses opening opportunities for therapeutic intervention. IGF-1R bears structural and functional resemblance to other tyrosine kinase receptors. Upon IGF binding the receptor is activated and autophosphorylated at the tyrosine residues in intracellular subunits leading to signaling via MAPK and PI3K/Akt pathways. Many tumors and transformed cells have altered IFG-1R expression. Recently the receptor came under the attention of roles in immune regulation. Proinflammatory cytokines, of which many share signaling components like Erk MAP kinases, seem to dampen several components of the IGF pathway. Furthermore, IGF regulates diverse aspects of T-cell, B-cell and monocyte function suggesting a role in pathogenesis of diseases where immunity is altered, like rheumatoid arthritis and IBD. Antibody 1B1 recognizes the extracellular domain if IGF-1R.
Product Categories/Family for anti-IGF-1R antibody
References
1. Nakadate, Y et al; Generation of a Monoclonal Antibody Against the Extracellular Domain of IGF-1R. Monoclonal antibodies in immunodiagnosis and immunotherapy, 2014, 2:126.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
insulin-like growth factor 1 receptor
NCBI Official Synonym Full Names
insulin like growth factor 1 receptor
NCBI Official Symbol
IGF1R
NCBI Official Synonym Symbols
IGF-1R
NCBI Protein Information
insulin-like growth factor 1 receptor
Research Articles on IGF-1R
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Product Notes
The IGF-1R (Catalog #AAA584818) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The IGF-1R, Human, mAb 1B1 reacts with Human and may cross-react with other species as described in the data sheet. The typical starting working dilution is 1:50. Researchers should empirically determine the suitability of the IGF-1R for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IGF-1R, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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