Western Blot (WB)
Mouse anti-Human Urocortin-2 Monoclonal Antibody | anti-UCN2 antibody
Urocortin-2, Human, mAb 2D7
Gene Names
UCN2; UR; SRP; URP; UCNI; UCN-II
Reactivity
Human
Applications
Western Blot
Synonyms
Urocortin-2; Monoclonal Antibody; Human; mAb 2D7; anti-UCN2 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Form/Format
1 ml (100 ug/ml) 0.2 um filtered protein G purified antibody solution in PBS, 0.1% bovine serum albumin and 0.02% sodium azide.
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)
Sequence Length
112
Applicable Applications for anti-UCN2 antibody
Immunoassay, Western Blot (WB)
Application Notes
The typical starting working dilution is 1:50.
Preparation and Storage
Should be stored at 4 degree C.
Under recommended storage conditions, product is stable for at least one year.
Under recommended storage conditions, product is stable for at least one year.
Western Blot (WB)
Western Blot (WB)
Related Product Information for anti-UCN2 antibody
Monoclonal antibody 2D7 recognizes the pro-region of Urocortin-2. Urocortins 1, 2 and 3 (Ucn I, Ucn II, and Ucn III), members of the corticotropin releasing factor (CRF)4 family, have diverse bioactivities and participate in the neuroendocrine responses to stress, appetite suppression, immunomodulation, energy and water homeostasis, and cardiovascular function. Their actions are mediated through the 7-transmembrane G-protein coupled receptors CRFR1 and CRFR2. Ucn1 binds to both receptors, whereas Ucn II and Ucn III are specific to CRFR2, widely expressed in the brain, heart, vasculature, and peripheral tissues. Binding of Ucn II to its receptor triggers an intricate signaling cascade via protein kinase C, phosphatidylinositol-3-kinase/Akt and mitogen-activated protein kinase pathways to modulate cytokine expression, cell proliferation, and apoptotic responses. The presence of Ucn II and CRFR2 in the heart and vasculature suggest a potentially important role for Ucn II in the physiology and pathophysiology of the circulation in health and cardiovascular disease. Urocortins exert beneficial effects in experimental cardiovascular disease models and may have therapeutic potential. The sequence of the mature human Ucn II neuropeptide is IVLSLDVPIGLLQILLEQARARAAREQATTNARILARV.
Product Categories/Family for anti-UCN2 antibody
References
1. Liew, O et al, His6-SUMO-eXact tag for producing human prepro-Urocortin 2 in Escherichia coli for raising monoclonal antibodies. J Immunol Method 2014, 403:37.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
12,146 Da
NCBI Official Full Name
urocortin-2 preproprotein
NCBI Official Synonym Full Names
urocortin 2
NCBI Official Symbol
UCN2
NCBI Official Synonym Symbols
UR; SRP; URP; UCNI; UCN-II
NCBI Protein Information
urocortin-2
UniProt Protein Name
Urocortin-2
Protein Family
UniProt Gene Name
UCN2
UniProt Synonym Gene Names
SRP; URP; Ucn II
NCBI Description
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]
Uniprot Description
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
Research Articles on UCN2
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Product Notes
The UCN2 ucn2 (Catalog #AAA584817) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Urocortin-2, Human, mAb 2D7 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Urocortin-2 can be used in a range of immunoassay formats including, but not limited to, Immunoassay, Western Blot (WB). The typical starting working dilution is 1:50. Researchers should empirically determine the suitability of the UCN2 ucn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Urocortin-2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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