Testing Data
(Purification of IgD. (a) Elution profile of the final Superdex S200 gel-filtration column. IgD was eluted as a single peak from which fractions 2 -4 were concentrated for the scattering experiments. (b) SDS-PAGE analysis of IgD (lane 1) and molecular mass markers (lane 2) run under reducing conditions and stained with Coomassie brilliant blue. Molecular masses are shown in kDa. (c) Western blot analysis of IgD (lane 1) from reducing SDS-PAGE. Image from: Sun et al (2005). JMB 353: 155-73. Western blot detection of IgD accomplished using Mouse anti Human IgD (Fc))
Mouse IgD Monoclonal Antibody | anti-IgD antibody
MOUSE ANTI HUMAN IgD (Fc)
Purified IgG - liquid
Preparation
Shelf Life: 18 months from date of despatch.
Testing Data
(Purification of IgD. (a) Elution profile of the final Superdex S200 gel-filtration column. IgD was eluted as a single peak from which fractions 2 -4 were concentrated for the scattering experiments. (b) SDS-PAGE analysis of IgD (lane 1) and molecular mass markers (lane 2) run under reducing conditions and stained with Coomassie brilliant blue. Molecular masses are shown in kDa. (c) Western blot analysis of IgD (lane 1) from reducing SDS-PAGE. Image from: Sun et al (2005). JMB 353: 155-73. Western blot detection of IgD accomplished using Mouse anti Human IgD (Fc))
Testing Data
(Purification of IgD. (a) Elution profile of the final Superdex S200 gel-filtration column. IgD was eluted as a single peak from which fractions 2 -4 were concentrated for the scattering experiments. (b) SDS-PAGE analysis of IgD (lane 1) and molecular mass markers (lane 2) run under reducing conditions and stained with Coomassie brilliant blue. Molecular masses are shown in kDa. (c) Western blot analysis of IgD (lane 1) from reducing SDS-PAGE. Image from: Sun et al (2005). JMB 353: 155-73. Western blot detection of IgD accomplished using Mouse anti Human IgD (Fc))
NCBI and Uniprot Product Information
Uniprot Description
IGHD: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 14q32.33
Cellular Component: plasma membrane; integral to membrane
Molecular Function: antigen binding
Biological Process: immune response
Research Articles on IgD
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Product Notes
The IgD ighd (Catalog #AAA213109) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's IgD can be used in a range of immunoassay formats including, but not limited to, Immunohistology Frozen. Immunohistology - Frozen: Minimum Dilution: 1/100; Maximum Dilution: 1/300. Researchers should empirically determine the suitability of the IgD ighd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IgD, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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