Rabbit anti-Human IGHD Polyclonal Antibody | anti-IGHD antibody

IGHD Antibody

Cat. Num. AAA7052073

• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G purified
• Synonyms: IGHD; Polyclonal Antibody; IGHD Antibody; Ig delta chain C region; anti-IGHD antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 384

• Applicable Applications for anti-IGHD antibody: ELISA (EIA)
• Immunogen: Recombinant Human Ig delta chain C region protein (1-240AA)
• Conjugation: Non-conjugated
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western BlotPositive WB detected in: Mouse brain tissueAll lanes: IGHD antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 43,38 KDaObserved band size: 43 KDa)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of human tonsil tissue using MBS7052073 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of human kidney tissue using MBS7052073 at dilution of 1:100)

Related Product Information for anti-IGHD antibody

IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.

NCBI and Uniprot Product Information

• NCBI GI #: 193806360
• NCBI GeneID: 3495
• UniProt Accession #: P01880; Q6P4I8; Q8WU38
• Molecular Weight: 47,401 Da
• NCBI Official Full Name: Ig delta chain C region
• NCBI Official Synonym Full Names: immunoglobulin heavy constant delta
• NCBI Official Symbol: IGHD
• UniProt Protein Name: Ig delta chain C region
• Protein Family: Ig delta chain C region
• UniProt Gene Name: IGHD

Uniprot Description

IGHD: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: external side of plasma membrane; plasma membrane

Molecular Function: antigen binding

Biological Process: B cell receptor signaling pathway; complement activation, classical pathway; defense response to bacterium; innate immune response; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of B cell activation