IgD, Human Myeloma Plasma Immunoglobulin | IGHD immunoglobulin

IgD, Human Myeloma Plasma

Cat. Num. AAA135570

• Purity: >95% by SDS-PAGE analysis
• Synonyms: IgD; Human Myeloma Plasma; IGHD immunoglobulin

• Host: Human myeloma plasma
• Purity/Purification: >95% by SDS-PAGE analysis
• Form/Format: Frozen liquid; 0.01M Tris-HCl; 0.15M NaCl; 0.01M EACA; 0.05% Azide; pH 8.0
• Concentration: .964 mg/ml (varies by lot)
• Sequence Length: 384

• Extinction Coefficient: 1.7
• Preservative: SodiumAzide
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Store at -70 degree C.; Shelf Life: 3 years from delivery; Ships in dry ice

Testing Data

Related Product Information for IGHD immunoglobulin

IgD was first identified in 1965, and like other immunoglobulins, exists as both secreted and membrane forms. Its level in plasma is low with a mean concentration of 30 ug/ml. IgD is present in large quantities on the surface membrane of a majority of human circulating B lymphocytes. IgD enhances humoral immune responses through its induction of IgD-receptor expression on T lymphocytes. Ref.: Coico RF, Siskind GW, Thorbecke GJ 1988. Immunol. Rev. 105:45. Prepared from myeloma plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. >95percent pure by SDS-PAGE.

Product Categories/Family for IGHD immunoglobulin

Human Immunoglobulins; Human Immunoglobulins

NCBI and Uniprot Product Information

• NCBI GI #: 193806360
• NCBI GeneID: 3495
• UniProt Accession #: P01880; Q6P4I8; Q8WU38
• Molecular Weight: 185,000
• NCBI Official Full Name: Ig delta chain C region
• NCBI Official Synonym Full Names: immunoglobulin heavy constant delta
• NCBI Official Symbol: IGHD
• UniProt Protein Name: Ig delta chain C region
• Protein Family: Ig delta chain C region
• UniProt Gene Name: IGHD
• UniProt Entry Name: IGHD_HUMAN

Uniprot Description

IGHD: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: integral to membrane; plasma membrane

Molecular Function: antigen binding

Biological Process: immune response