Rabbit anti-Human IFNAR2  Monoclonal Antibody | anti-IFNAR2  antibody

Rabbit anti Human IFNAR2  Monoclonal Antibody

Cat. Num. AAA2543955

• Gene Names: IFNAR2; IFN-R; IMD45; IFNABR; IFNARB; IFN-alpha-REC
• Reactivity: Human
• Applications: ELISA
• Synonyms: IFNAR2 ; Monoclonal Antibody; Rabbit anti Human IFNAR2 Monoclonal Antibody; anti-IFNAR2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 239

• Applicable Applications for anti-IFNAR2 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human IFNAR2. The detection limit for Human IFNAR2 is approximately 0.00245 ng/well.
• Immunogen: Recombinant Human IFNAR2 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-IFNAR2  antibody

Interferon-alpha/beta receptor beta chain (IFNAR2) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Initial cell-surface IFNAR2 expression at identification assessed by flow cytometry widely distributed but showed overall significantly higher expression in CML patients when compared with normal controls. In 15 fresh patients who subsequently received IFNalpha therapy, IFNAR2 expression at identification was significantly higher in cytogenetic good responders than in poor responders. Down-regulation of IFNAR2 expression during IFNalpha therapy was observed only in good responders but not in poor responders. The encoded protein also functions as an antiviral factor. IFNAR2 may associate with IFNAR1 to form the type I interferon receptor. This protein serves as a receptor for interferons alpha and beta. IFNAR2 is also involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Following binding of IFNalpha2, IFNAR2 is internalized, but, instead of being routed towards degradation as it is when complexed to IFNbeta, it recycles back to the cell surface.

NCBI and Uniprot Product Information

• NCBI GI #: 574584813
• NCBI GeneID: 3455
• NCBI GenBank Nucleotide #: NM_001289128.1
• Molecular Weight: 27,384 Da
• NCBI Official Full Name: interferon alpha/beta receptor 2 isoform c
• NCBI Official Synonym Full Names: interferon alpha and beta receptor subunit 2
• NCBI Official Symbol: IFNAR2
• NCBI Official Synonym Symbols: IFN-R; IMD45; IFNABR; IFNARB; IFN-alpha-REC
• NCBI Protein Information: interferon alpha/beta receptor 2
• UniProt Protein Name: Interferon alpha/beta receptor 2
• UniProt Gene Name: IFNAR2
• UniProt Synonym Gene Names: IFNABR; IFNARB; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2
• UniProt Entry Name: INAR2_HUMAN

NCBI Description

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

IFNAR2: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: extracellular region; integral to plasma membrane; plasma membrane

Molecular Function: interferon-alpha/beta receptor activity; interleukin-20 binding; protein binding; protein kinase binding

Biological Process: cell surface receptor linked signal transduction; defense response to virus; JAK-STAT cascade; response to virus

Disease: Hepatitis B Virus, Susceptibility To; Immunodeficiency 45