Mouse anti-Mouse IFN alpha R1 Monoclonal Antibody | anti-Ifnar1 antibody
IFN alpha R1 Antibody
Gene Names
Ifnar1; Ifar; Ifrc; CD118; Ifnar; Infar
Reactivity
Mouse
Applications
Western Blot, Immunoprecipitation, Flow Cytometry, Functional Assay
Purity
ProA affinity purified
Synonyms
IFN alpha R1; Monoclonal Antibody; IFN alpha R1 Antibody; Alpha type antiviral protein antibody; Antiviral protein; alpha-type antibody; beta-type antibody; AVP antibody; Beta type antiviral protein antibody; CRF2-1 antibody; Cytokine receptor class-II member 1 antibody; Cytokine receptor family 2 member 1 antibody; IFN alpha REC antibody; IFN alpha receptor antibody; IFN alpha/beta Receptor alpha antibody; IFN beta receptor antibody; IFN Interferon-beta receptor antibody; IFN-alpha/beta receptor 1 antibody; IFN-R-1 antibody; IFNAR antibody; Ifnar1 antibody; IFNBR antibody; IFRC antibody; INAR1_HUMAN antibody; Interferon (alpha beta and omega) receptor 1 antibody; interferon alpha and beta receptor subunit 1 antibody; Interferon alpha/beta receptor 1 antibody; Interferon alpha/beta receptor alpha chain antibody; Interferon beta receptor 1 antibody; interferon receptor 1 antibody; Interferon-alpha receptor antibody; Type I interferon receptor 1 antibody; anti-Ifnar1 antibody
Host
Mouse
Reactivity
Mouse
Clonality
Monoclonal
Clone Number
2G1
Purity/Purification
ProA affinity purified
Form/Format
1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Applicable Applications for anti-Ifnar1 antibody
Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Application Notes
WB: 1:100-1:1000
IP: 1-2ug per 100-500ug of total protein (1 ml of cell lysate)
FC/FACS: 1ug per 1 x 106 cells
IP: 1-2ug per 100-500ug of total protein (1 ml of cell lysate)
FC/FACS: 1ug per 1 x 106 cells
Immunogen
The extracellular domain of IFN-alphaR1 of mouse origin.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C.
Related Product Information for anti-Ifnar1 antibody
The type I interferons (IFNs), and, are a group of structurally and functionally related proteins that are induced by either viruses or double stranded RNA and defined by their ability to confer an antiviral state in cells. The and IFNs appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFN) binds to a distinct receptor. The latter protein, IFN-R, is only weakly responsive to type I interferons in contrast to IFN-/R, which binds to and responds effectively to IFN- and to several of the IFN- subtypes. Moreover, IFN-/R is physically associated with the cytoplasmic tyrosine kinase JAK1 and thus, in addition to ligand binding, appears to be functionally involved in signal transduction. IFN-R1 is a receptor for IFN-/ and is present as the full chain (IFN-R1a) and as a splice-variant (IFN-R1). The IFN- receptor complex consists of an alpha subunit (IFN-R) and a beta subunit that is 332 amino acids in length (mouse) and 337 amino acids in length (human).
Product Categories/Family for anti-Ifnar1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
65,796 Da
NCBI Official Full Name
interferon alpha/beta receptor 1
NCBI Official Synonym Full Names
interferon (alpha and beta) receptor 1
NCBI Official Symbol
Ifnar1
NCBI Official Synonym Symbols
Ifar; Ifrc; CD118; Ifnar; Infar
NCBI Protein Information
interferon alpha/beta receptor 1
UniProt Protein Name
Interferon alpha/beta receptor 1
Protein Family
UniProt Gene Name
Ifnar1
UniProt Synonym Gene Names
Ifar; Ifnar; IFN-R-1; IFN-alpha/beta receptor 1
Uniprot Description
IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 16 C3.3|16 52.98 cM
Cellular Component: integral to plasma membrane
Molecular Function: interferon receptor activity; interferon-alpha/beta binding; interferon-alpha/beta receptor activity
Biological Process: defense response to virus; interferon type I biosynthetic process; positive regulation of interferon-beta production; positive regulation of interferon-gamma production; positive regulation of interleukin-1 beta secretion; positive regulation of transcription, DNA-dependent; regulation of peptidyl-tyrosine phosphorylation; response to lipopolysaccharide; T cell activation
Research Articles on Ifnar1
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Product Notes
The Ifnar1 ifnar1 (Catalog #AAA9435168) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The IFN alpha R1 Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's IFN alpha R1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS). WB: 1:100-1:1000 IP: 1-2ug per 100-500ug of total protein (1 ml of cell lysate) FC/FACS: 1ug per 1 x 106 cells. Researchers should empirically determine the suitability of the Ifnar1 ifnar1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IFN alpha R1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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