Rabbit anti-Human ICAM-2 Monoclonal Antibody | anti-ICAM2 antibody

Recombinant Anti-ICAM-2 Antibody, Rabbit Monoclonal

Cat. Num. AAA8102294

• Gene Names: ICAM2; CD102
• Reactivity: Human
• Applications: Western Blot
• Purity: Protein A
• Synonyms: ICAM-2; Monoclonal Antibody; Recombinant Anti-ICAM-2 Antibody; Rabbit Monoclonal; ICAM-2/CD102 Antibody; Rabbit MAb; intercellular adhesion molecule 2; Anti-CD102 Antibody; anti-ICAM2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 033
• Specificity: Human ICAM-2/CD102
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-ICAM2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant Human ICAM-2/CD102 protein
• Conjugation: Unconjugated
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human ICAM-2/CD102 (rh ICAM-2/CD102).
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Western Blot (WB)

(Anti-ICAM2 rabbit monoclonal antibody at 1:500 dilutionLane A: HelaS3 Whole Cell LysateLysates/proteins at 30 ug per lane.SecondaryGoat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.Developed using the Odyssey technique. Performed under reducing conditions.Predicted band size:31 kDaObserved band size:37 kDa)

Related Product Information for anti-ICAM2 antibody

Intercellular adhesion molecule 2 (ICAM-2, CD102), belongs to the ICAM family consisting of three members identified as ligands for integrin receptors. It is a type I transmembrane glycoprotein with two Ig-like C2-type domains and binds to the leukocyte integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). As the second ligand of leukocyte function-associated antigen-1, ICAM-2 functions as a costimulatory molecule for effector cells. ICAM-2 is mainly expressed on vascular endothelial and hematopoietic cells. Interactions of ICAM-2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocyte with other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity, and migration, lymphocyte recirculation, etc. Serum levels of ICAM-2 correlated significantly with the inflammatory and course sequences of trichinosis in mice and had a similar relationship with blood eosinophilia. So, estimation of ICAM-2 serum levels may prove useful in the identification of trichinosis recent infections, and in monitoring the prognosis and response to treatment.

References

Weber KS, et al. (2004) Sialylation of ICAM-2 on platelets impairs adhesion of leukocytes via LFA-1 and DC-SIGN. Inflammation. 28(4): 177-88.Tanaka H, et al. (2004) ICAM-2 gene therapy for peritoneal dissemination of scirrhous gastric carcinoma. Clin Cancer Res. 10(14): 4885-92.Younis AI, et al. (2005) Intercellular adhesion molecule-2 (ICAM-2) in experimental trichinosis. J Egypt Soc Parasitol. 35(3): 1019-26.

NCBI and Uniprot Product Information

• NCBI GI #: 153082696
• NCBI GeneID: 3384
• NCBI Accession #: NP_000864.2
• NCBI GenBank Nucleotide #: NM_000873.3
• UniProt Accession #: P13598; Q14600
• Molecular Weight: 30,654 Da
• NCBI Official Full Name: intercellular adhesion molecule 2
• NCBI Official Synonym Full Names: intercellular adhesion molecule 2
• NCBI Official Symbol: ICAM2
• NCBI Official Synonym Symbols: CD102
• NCBI Protein Information: intercellular adhesion molecule 2; ICAM-2
• UniProt Protein Name: Intercellular adhesion molecule 2
• Protein Family: Intercellular adhesion molecule
• UniProt Gene Name: ICAM2
• UniProt Synonym Gene Names: ICAM-2
• UniProt Entry Name: ICAM2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ICAM2: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Belongs to the immunoglobulin superfamily. ICAM family.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: membrane; integral to plasma membrane; plasma membrane; uropod

Molecular Function: integrin binding

Biological Process: cell-cell adhesion; regulation of immune response; extracellular matrix organization and biogenesis; cell adhesion